Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection
Background
Post-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression of the...
Abstract
Recent studies have reported that plasma levels of tricarboxylic acid (TCA) cycle metabolites and TCA cycle-related metabolite change in patients with chronic fatigue syndrome (CFS) and in healthy humans after exercise. Exogenous dietary citric acid has been reported to alleviate...
Researchers have new insights into the citric acid cycle: Certain bacteria can use this central metabolic pathway 'backwards', but to do so they must have very high concentrations of the enzyme citrate synthase and of carbon dioxide. This pathway may be a relic from the early development of...
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