calcium

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space Moreno-Villanueva, Maria; Jimenez-Chavez, Luis E.; Krieger, Stephanie; Ding, Liang-Hao; Zhang, Ye; Babiak-Vazquez, Adriana; Berres, Mark; Splinter...

Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease Prevalence in High-Risk Individuals Jason Sardell; Sayoni Das; Krystyna Taylor; Colin Stubberfield; Andy Malinowski; Mark Strivens; Steve Gardner We present a novel...

Abstract Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism. Giulia Dematteis; Laura Tapella; Claudio Casali; Maria Talmon; Elisa Tonelli; Simone Reano; Adele Ariotti; Emanuela Pessolano; Mustyna Malecka; Gabriela Chrostek; Gabriele...

Abstract Spending time in a microgravity environment is known to cause significant skeletal muscle atrophy and weakness via muscle unloading, which can be partly attributed to Ca2+ dysregulation. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for bringing Ca2+ from...

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID Vishnu Shankar; Julie Wilhelmy; Basil Michael; Layla Cervantes; Vamsee Mallajosyula; Ronald Davis; Michael Snyder; Shady Younis; William H Robinson; Sadasivan Shankar; Paul Mischel; Hector Bonilla; Mark Davis More than 65...

Disuse-Induced Muscle Fatigue: Facts and Assumptions Sergeeva, Xenia V.; Lvova, Irina D.; Sharlo, Kristina A. Skeletal muscle unloading occurs during a wide range of conditions, from space flight to bed rest. The unloaded muscle undergoes negative functional changes, which include increased...

Unraveling the Connection: Pain and Endoplasmic Reticulum Stress Kawanaka, Ryoko; Jin, Hisayo; Aoe, Tomohiko Pain is a complex and multifaceted experience. Recent research has increasingly focused on the role of endoplasmic reticulum (ER) stress in the induction and modulation of pain. The ER...

Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling multisystemic condition. The pathomechanism of ME/CFS remains unestablished; however, impaired natural killer (NK) cell cytotoxicity is a consistent feature of this condition. Calcium (Ca2+) is crucial for NK...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS remains elusive, reduced natural killer (NK) cell cytotoxic function is a consistent immunological feature. NK cell effector functions...

Abstract The transient receptor potential (TRP) superfamily of ion channels is involved in the molecular mechanisms that mediate neuroimmune interactions and activities. Recent advancements in neuroimmunology have identified a role for TRP cation channels in several neuroimmune disorders...

Split thread from Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain, Md Shafiqur Rahman, et al, 2020 *** I was reading about calcium channels the other day. This reference about them is very readable and interesting. Don't be put...

Abstract Background and Objectives Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable (48-54%), but its genetic architecture is unknown and candidate gene studies have produced inconsistent results...

I think this seems to be talking about the opposite of what Griffiths University claimed to have found here, https://www.s4me.info/threads/the-courier-mail-australian-scientists-prove-cfs-is-real-and-have-discovered-a-test-for-it.1638/? Griffiths claim we don't have enough calcium going into...