blood brain barrier

The S1 subunits of SARS-CoV-2 variants differentially trigger the IL-6 signaling pathway in human brain endothelial cells and downstream impact on microglia activation Michael Stangis; Daniel Adesse; Bhavya Sharma; Eduardo Castro; Kush Kumar; Neil Kumar; Masha Minevich; Michal Toborek...

Waste Clearance in the Brain Kaur, Jasleen; Fahmy, Lara M.; Davoodi-Bojd, Esmaeil; Zhang, Li; Ding, Guangliang; Hu, Jiani; Zhang, Zhenggang; Chopp, Michael; Jiang, Quan Waste clearance (WC) is an essential process for brain homeostasis, which is required for the proper and healthy functioning...

Abstract The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude...

Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging Kilgore, Madison O.; Hubbard, W. Brad Low-level blast (LLB) exposure can lead to alterations in neurological health, cerebral vasculature, and cerebral blood...

The neurobiology of SARS-CoV-2 infection Meinhardt, Jenny; Streit, Simon; Dittmayer, Carsten; Manitius, Regina v.; Radbruch, Helena; Heppner, Frank L. Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated 55–60% of those infected developing COVID-19. Since the...

Blood-brain barrier breakdown in COVID-19 ICU survivors: an MRI pilot study Wen Shi; Dengrong Jiang; Hannah Rando; Shivalika Khanduja; Zixuan Lin; Kaisha Hazel; George Pottanat; Ebony Jones; Cuimei Xu; Doris Lin; Sevil Yasar; Sung-Min Cho; Hanzhang Lu Objectives Coronavirus disease 2019...

Circulating Metabolome and White Matter Hyperintensities in Women and Men Eeva Sliz; Jean Shin; Shahzad Ahmad; Dylan M. Williams; Stefan Frenzel; Friederike Gauß; Sarah E. Harris; Ann-Kristin Henning; Maria Valdes Hernandez; Yi-Han Hu; Beatriz Jiménez; Muralidharan Sargurupremraj; Carole Sudre...

COVID-19 and Long COVID: Disruption of the Neurovascular Unit, Blood-Brain Barrier, and Tight Junctions Duraisamy Kempuraj; Kristina K. Aenlle; Jessica Cohen; Annette Mathew; Dylan Isler; Rajendra P. Pangeni; Lubov Nathanson; Theoharis C. Theoharides; Nancy G. Klimas Severe acute respiratory...

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics Petersen, Mark A.; Ryu, Jae Kyu; Akassoglou, Katerina The blood coagulation protein fibrinogen is deposited in the brain in a wide range of neurological diseases and traumatic injuries with blood–brain barrier (BBB)...

Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functions Background Although mainly causing a respiratory syndrome, numerous neurological symptoms have been identified following of SARS-CoV-2 infection. However, how the virus affects the...

Preprint Blood-brain barrier disruption in Long COVID-associated cognitive impairment Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell Vascular disruption has been...

Full title: Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 Variants of Concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease Abstract COVID-19 and especially Long COVID are associated with severe CNS symptoms and may place persons...

Sex differences in the blood-brain barrier: Implications for mental health Dion-Albert L, Bandeira Binder L, Daigle B, Hong-Minh A, Lebel M, Menard C Prevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ) are increasing at...

Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations Bonetto V, Pasetto L, Lisi I, Carbonara M, Zangari R, Ferrari E, Punzi V, Luotti S, Bottino N, Biagianti B, Moglia C, Fuda G, Gualtierotti R, Blasi F, Canetta C...

Preprint See post 5 for published version Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer’s disease individuals Elizabeth Griggs, Kyle Trageser, Sean Naughton, Eun-Jeong Yang, Brian Mathew, Grace Van Hyfte, Linh Hellmers, Nathalie Jette, Molly Estill, Li Shen, Tracy...

Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study Etter MM, Martins TA, Kulsvehagen L, Pössnecker E, Duchemin W, Hogan S, Sanabria-Diaz G, Müller J, Chiappini A, Rychen J, Eberhard N, Guzman R, Mariani L...

Abstract Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer’s disease (AD). However, the mechanisms that link disruption of the blood–brain...

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction Fuyuko Takata, Shinsuke Nakagawa, Junichi Matsumoto, Shinya Dohgu Neuroinflammation is...

https://www.nature.com/articles/s41467-022-29657-y Abstract Blood-brain barrier (BBB) dysfunction is associated with worse epilepsy outcomes however the underlying molecular mechanisms of BBB dysfunction remain to be elucidated. Tight junction proteins are important regulators of BBB integrity...

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? Theoharis C. Theoharides Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine Abstract SARS-CoV-2 infects cells via its spike protein binding to its...