blood brain barrier

Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functions Background Although mainly causing a respiratory syndrome, numerous neurological symptoms have been identified following of SARS-CoV-2 infection. However, how the virus affects the...

Preprint Blood-brain barrier disruption in Long COVID-associated cognitive impairment Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell Vascular disruption has been...

Full title: Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 Variants of Concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease Abstract COVID-19 and especially Long COVID are associated with severe CNS symptoms and may place persons...

Sex differences in the blood-brain barrier: Implications for mental health Dion-Albert L, Bandeira Binder L, Daigle B, Hong-Minh A, Lebel M, Menard C Prevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ) are increasing at...

Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations Bonetto V, Pasetto L, Lisi I, Carbonara M, Zangari R, Ferrari E, Punzi V, Luotti S, Bottino N, Biagianti B, Moglia C, Fuda G, Gualtierotti R, Blasi F, Canetta C...

Preprint See post 5 for published version Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer’s disease individuals Elizabeth Griggs, Kyle Trageser, Sean Naughton, Eun-Jeong Yang, Brian Mathew, Grace Van Hyfte, Linh Hellmers, Nathalie Jette, Molly Estill, Li Shen, Tracy...

Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study Etter MM, Martins TA, Kulsvehagen L, Pössnecker E, Duchemin W, Hogan S, Sanabria-Diaz G, Müller J, Chiappini A, Rychen J, Eberhard N, Guzman R, Mariani L...

Abstract Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer’s disease (AD). However, the mechanisms that link disruption of the blood–brain...

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction Fuyuko Takata, Shinsuke Nakagawa, Junichi Matsumoto, Shinya Dohgu Neuroinflammation is...

https://www.nature.com/articles/s41467-022-29657-y Abstract Blood-brain barrier (BBB) dysfunction is associated with worse epilepsy outcomes however the underlying molecular mechanisms of BBB dysfunction remain to be elucidated. Tight junction proteins are important regulators of BBB integrity...

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? Theoharis C. Theoharides Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine Abstract SARS-CoV-2 infects cells via its spike protein binding to its...

COVID-19 induces neuroinflammation and loss of hippocampal neurogenesis Robyn Klein, Allison Soung, Cheick Sissoko, Anna Nordvig, Peter Canoll, Madeline Mariani, Xiaoping Jiang, Traci Bricker, James Goldman, Gorazd Rosoklija, Victoria Arango, Mark Underwood, John Mann, Adrianus Boon, Andrew...

Moderator note: Copied from this thread: "Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia... van Campen et al, 2020 _____________________________ There is this new article but sorry if it is old study news, I'm new to...

cc @Perrier I had a discussion with Jen Brea on Twitter regarding Traumatic Brain Injury (TBI) and ME. TBI was something i never looked at but i do recall that there are cases of patients that got ME after car accidents. I performed an analysis for TBI to summarise all available information...