blood brain barrier

SARS-Cov-2 Replication in a Blood–Brain Barrier Model Established with Human Brain Microvascular Endothelial Cells Induces Permeability and Disables ACE2-Dependent Regulation of Bradykinin B1 Receptor Coelho, Sharton Vinicius Antunes; Souza, Gabriela Lisboa e; Bezerra, Bruno Braz; Lima, Luan...

Long COVID-related blood-brain barrier breakdown and microstructure in older adults are modified by sex and Alzheimer’s disease genetic risk Emilie T. Reas, Austin Alderson-Myers, Seraphina K. Solders, Qian Shen, Charlotte S. Rivera, Xin Wang, Jordan Stiver, Sarah J. Banks, Jennifer S. Graves...

Crosstalk Among Disrupted Blood-Brain Barrier, Neuroinflammation, and Coagulopathy in AC70 hACE2 Tg Mice with Prolonged Neurological Manifestations Induced by the Omicron BA.1 Variant of SARS-CoV-2 Aleksandra K Drelich; Panatda Saenkham-Huntsinger; Yu-Hsiu E. Wang; Xuping Xie; Barbara M. Judy...

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease Shi, Sophia M.; Suh, Ryan J.; Shon, D. Judy; Garcia, Francisco J.; Buff, Josephine K.; Atkins, Micaiah; Li, Lulin; Lu, Nannan; Sun, Bryan; Luo, Jian; To, Ning-Sum; Cheung, Tom H.; McNerney, M. Windy; Heiman, Myriam...

Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health Fekete, Monika; Lehoczki, Andrea; Szappanos, Ágnes; Toth, Attila; Mahdi, Mohamed; Sótonyi, Péter; Benyó, Zoltán; Yabluchanskiy, Andriy; Tarantini, Stefano; Ungvari, Zoltan Long COVID (also known...

Abstract: Current research into mood disorders indicates that circulating immune mediators participating in the pathophysiology of chronic somatic disorders have potent influences on brain function. This paradigm has brought to the fore the use of anti-inflammatory therapies as adjunctive to...

Maternal COVID-19 infection associated with offspring neurodevelopmental disorders Duan, Lian; Yin, Huamin; Liu, Jiaxin; Wang, Wenhang; Huang, Peijun; Liu, Li; Shen, Jingling; Wang, Zhendong Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring...

Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates Thibaut Naninck; Alexandra Detrille; Steve Huvelle; Marit J. van Gils; Tatiana Geara; Quentin Pascal; Jonne Snitselaar; Laetitia Bossevot; Mariangela Cavarelli; Nathalie Bosquet; Francis...

Link - open access In mice Venkatramana D. Krishna1, Allison Chang2, Holly Korthas3, Susanna R. Var4, Davis M. Seelig5, Walter C. Low2,4*, Ling Li2,3* and Maxim C. -J. Cheeran1* Minnesota team Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is...

The choroid plexus synergizes with immune cells during neuroinflammation Huixin Xu; Peter Lotfy; Sivan Gelb; Aja Pragana; Christine Hehnly; Lillian I.J. Byer; Frederick B. Shipley; Miriam E. Zawadzki; Jin Cui; Liwen Deng; Milo Taylor; Mya Webb; Hart G.W. Lidov; Mark L. Andermann; Isaac M. Chiu...

Blood brain barrier disruption and glutamatergic excitotoxicity in post-acute sequelae of SARS COV-2 infection cognitive impairment: potential biomarkers and a window into pathogenesis Chaganti, Joga; Poudel, Govinda; Cysique, Lucette Adeline; Dore, Gregory J.; Kelleher, Anthony; Matthews, Gael...

The S1 subunits of SARS-CoV-2 variants differentially trigger the IL-6 signaling pathway in human brain endothelial cells and downstream impact on microglia activation Michael Stangis; Daniel Adesse; Bhavya Sharma; Eduardo Castro; Kush Kumar; Neil Kumar; Masha Minevich; Michal Toborek...

Waste Clearance in the Brain Kaur, Jasleen; Fahmy, Lara M.; Davoodi-Bojd, Esmaeil; Zhang, Li; Ding, Guangliang; Hu, Jiani; Zhang, Zhenggang; Chopp, Michael; Jiang, Quan Waste clearance (WC) is an essential process for brain homeostasis, which is required for the proper and healthy functioning...

Abstract The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude...

Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging Kilgore, Madison O.; Hubbard, W. Brad Low-level blast (LLB) exposure can lead to alterations in neurological health, cerebral vasculature, and cerebral blood...

The neurobiology of SARS-CoV-2 infection Meinhardt, Jenny; Streit, Simon; Dittmayer, Carsten; Manitius, Regina v.; Radbruch, Helena; Heppner, Frank L. Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated 55–60% of those infected developing COVID-19. Since the...

Blood-brain barrier breakdown in COVID-19 ICU survivors: an MRI pilot study Wen Shi; Dengrong Jiang; Hannah Rando; Shivalika Khanduja; Zixuan Lin; Kaisha Hazel; George Pottanat; Ebony Jones; Cuimei Xu; Doris Lin; Sevil Yasar; Sung-Min Cho; Hanzhang Lu Objectives Coronavirus disease 2019...

Circulating Metabolome and White Matter Hyperintensities in Women and Men Eeva Sliz; Jean Shin; Shahzad Ahmad; Dylan M. Williams; Stefan Frenzel; Friederike Gauß; Sarah E. Harris; Ann-Kristin Henning; Maria Valdes Hernandez; Yi-Han Hu; Beatriz Jiménez; Muralidharan Sargurupremraj; Carole Sudre...

COVID-19 and Long COVID: Disruption of the Neurovascular Unit, Blood-Brain Barrier, and Tight Junctions Duraisamy Kempuraj; Kristina K. Aenlle; Jessica Cohen; Annette Mathew; Dylan Isler; Rajendra P. Pangeni; Lubov Nathanson; Theoharis C. Theoharides; Nancy G. Klimas Severe acute respiratory...

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics Petersen, Mark A.; Ryu, Jae Kyu; Akassoglou, Katerina The blood coagulation protein fibrinogen is deposited in the brain in a wide range of neurological diseases and traumatic injuries with blood–brain barrier (BBB)...