autophagy

  1. Dolphin

    Heat vs. Fatigue: Hyperthermia as a Possible Treatment Option for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2025, Hochecker

    https://www.mdpi.com/1422-0067/26/11/5339# Open Access Article Heat vs. Fatigue: Hyperthermia as a Possible Treatment Option for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) by Barbara Hochecker 1,*, Katja Matt 1, Melanie Scherer 1, Alica Meßmer 1, Alexander von Ardenne 2...
    • Dolphin
    • Thread
    • autophagy bip grp78 hsp hyperthermia mitochondria oxygen use seahorse sod2 ulk
    • Replies: 18
    • Forum: ME/CFS research
  2. forestglip

    Trial Report Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy, 2025, Ruan et al

    Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy Brian T. Ruan, Sarojini Bulbule, Amy Reyes, Bela Chheda, Lucinda Bateman, Jennifer Bell, Braydon Yellman, Stephanie Grach, Jon Berner, Daniel L. Peterson, David Kaufman, Avik Roy...
    • forestglip
    • Thread
    • atg13 autophagy beclin-1 me/cfs mtor pser258-atg13 rapamycin
    • Replies: 18
    • Forum: ME/CFS research
  3. SNT Gatchaman

    Preprint MAVS Orchestrates a Potent IFN-independent Antiviral Immunity by Preserving Mitochondrial Integrity, 2025, Sah et al.

    MAVS Orchestrates a Potent IFN-independent Antiviral Immunity by Preserving Mitochondrial Integrity Vishal Sah; Poojitha Sai Potharaju; Karthika S Nair; Prangya Paramita Sahoo; Abhiram Ravicanti Pooja; Debasmita Basu; Dixit Tandel; K S Varadarajan; Santosh Chauhan; Anant Bahadur Patel; Krishnan...
  4. SNT Gatchaman

    Preprint Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease…, 2025, Sardell+

    Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease Prevalence in High-Risk Individuals Jason Sardell; Sayoni Das; Krystyna Taylor; Colin Stubberfield; Andy Malinowski; Mark Strivens; Steve Gardner We present a novel...
    • SNT Gatchaman
    • Thread
    • als ampk autophagy calcium cytoskeleton gwas insulin precisionlife red blood cells slc15a4 snp
    • Replies: 4
    • Forum: ME/CFS research
  5. SNT Gatchaman

    Relationship of Autophagic Dysfunction With Quality of Life and Sleep, Depression and Disease Severity in […] Restless Legs Syndrome, 2025, Çiçekli+

    Relationship of Autophagic Dysfunction With the Quality of Life and Sleep, Depression and Disease Severity in Patients With Restless Legs Syndrome Esen Çiçekli; Hamza Malik Okuyan; Canan Birimoğlu Okuyan; Şeyda Öznur Ayçiçek; Dilcan Kotan INTRODUCTION Restless legs syndrome (RLS) is a...
  6. SNT Gatchaman

    Review Mitochondrial quality control pathways sense mitochondrial protein import, 2023, Laurie P. Lee-Glover and Timothy E. Shutt

    Mitochondrial quality control pathways sense mitochondrial protein import Laurie P. Lee-Glover; Timothy E. Shutt Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from...
    • SNT Gatchaman
    • Thread
    • autophagy cell signalling fgf21 integrated stress response metabolism mitochondria mitophagy steroids unfolded protein response upr
    • Replies: 1
    • Forum: Other health news and research
  7. Dolphin

    Trial Report Heat treatment in health and disease: How water-filtered infrared-A (wIRA irradiation affects key cellular mechanisms in ME/CFS, 2024, Hochecker

    https://www.sciencedirect.com/science/article/abs/pii/S0306456524000317 Journal of Thermal Biology Available online 21 February 2024, 103813 In Press, Journal Pre-proof Heat treatment in health and disease: How water-filtered infrared-A (wIRA irradiation affects key cellular mechanisms in...
    • Dolphin
    • Thread
    • ampk atg7 autophagy hsp70 infrared mitochondria seahorse sirt
    • Replies: 5
    • Forum: ME/CFS research
  8. SNT Gatchaman

    The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics, 2023, Pileggi et al.

    The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics Pileggi; Parmar; Elkhatib; Stewart; Alecu; Côté; Bennett; Sandhu; Cuperlovic-Culf; Harper SARS-CoV-2 infection is associated with both acute and post-acute neurological symptoms. Emerging evidence...
    • SNT Gatchaman
    • Thread
    • autophagy mitochondria mitophagy monoamine oxidase neurodegenerative disease parkinsons sars-cov-2 spike protein
    • Replies: 18
    • Forum: Long Covid research
  9. SNT Gatchaman

    Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs, 2021, Todkar et al.

    Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs Todkar, Kiran; Chikhi, Lilia; Desjardins, Véronique; El-Mortada, Firas; Pépin, Geneviève; Germain, Marc Most cells constitutively secrete mitochondrial DNA and proteins in...
  10. SNT Gatchaman

    Review Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease, 2023, Boardman, Wüst et al.

    Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease Boardman, Neoma T; Trani, Giulia; Scalabrin, Marco; Romanello, Vanina; Wüst, Rob C I Mitochondria sense both biochemical and energetic input in addition to communicating signals regarding the...
  11. SNT Gatchaman

    [Preprint] Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy, 2023, Lee et al.

    Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy Jae Seung Lee; Mark Dittmar; Jesse Miller; Minghua Li; Kasirajan Ayyanathan; Max B Ferretti; Jesse Hulahan; Kanupriya Whig; Zienab Etwebi; Trevor Griesman; David C. Schultz; Sara Cherry...
  12. Andy

    Lactate is a bridge linking glycolysis and autophagy through lactylation 2023 Cheng et al

    Lactate is a glycolysis product that is produced from pyruvate by LDH (lactate dehydrogenase) and plays an important role in physiological and pathological processes. However, whether lactate regulates autophagy is still unknown. We recently reported that LDHA is phosphorylated at serine 196 by...
  13. SNT Gatchaman

    Preprint Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms, 2023, Romenskaja et al.

    Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms Diana Romenskaja; Ugne Jonavice; Augustas Pivoriunas Autophagy dysfunction has been closely related with pathogenesis of many neurodegenerative diseases and therefore represents a potential...
  14. SNT Gatchaman

    ULK phosphorylation of STX17 controls autophagosome maturation via FLNA, 2023, Wang et al.

    ULK phosphorylation of STX17 controls autophagosome maturation via FLNA Wang, Yufen; Que, Huilin; Li, ChuangPeng; Wu, Zhe; Jian, Fenglei; Zhao, Yuan; Tang, Haohao; Chen, Yang; Gao, Shuaixin; Wong, Catherine C.L.; Li, Ying; Zhao, Chongchong; Rong, Yueguang Autophagy is a conserved and tightly...
  15. belbyr

    mTOR activation, ATG13 inactivation and suppression of autophagy

    Split from USA: NIH National Institutes of Health news Avik Roy and Gunnar Gottschalk presented their hypothesis on a NIH ME/CFS working Group call A relevant paper is Elevated ATG13 in serum of pwME stimulates oxidative stress response in microglial cells , 2022, Gottschalk et al...
  16. SNT Gatchaman

    Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies, 2023

    Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies Robinson CA, Singh GK, Kleer M, Katsademas T, Castle EL, Boudreau BQ, Corcoran JA Kaposi’s sarcoma-associated herpesvirus (KSHV) causes the inflammatory and...
  17. SNT Gatchaman

    Life and Death Decisions-The Many Faces of Autophagy in Cell Survival and Cell Death (2022, Yu and Klionsky)

    Life and Death Decisions-The Many Faces of Autophagy in Cell Survival and Cell Death Yu G, Klionsky DJ Autophagy is a process conserved from yeast to humans. Since the discovery of autophagy, its physiological role in cell survival and cell death has been intensively investigated. The inherent...
  18. SNT Gatchaman

    Galectins at a glance, 2018, Johannes et al

    Galectins at a glance Ludger Johannes, Ralf Jacob, Hakon Leffler Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis...
  19. Sly Saint

    Elevated ATG13 in serum of pwME stimulates oxidative stress response in microglial cells , 2022, Gottschalk et al

    For the abstract of the published paper, go to post #9 Preprint Abstract Myalgic Encephalomyelitis and chronic fatigue syndrome is a multisystem illness characterized with extreme muscle fatigue associated with pain, neurocognitive impairment, and chronic inflammation. Despite intense...
    • Sly Saint
    • Thread
    • alpha-synuclein atg13 autophagy avik roy blood gottschalk me/cfs microglia nitric oxide simmaron something in the blood
    • Replies: 72
    • Forum: ME/CFS research
  20. Andy

    SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals, 2021, Gassen et al

    Abstract Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular...
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