antivirals

Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA PAX LC: a double-blind, randomised, placebo-controlled, phase 2, decentralised trial Mitsuaki Sawano; Bornali Bhattacharjee; César Caraballo; Rohan Khera; Shu-Xia Li; Jeph Herrin; Dany Christian; Andreas...

Association between long COVID and nonsteroidal anti-inflammatory drug use by patients with acute-phase COVID-19: A nationwide Korea National Health Insurance Service cohort study Ye-Seul Lee, Heejun Kim, Sunoh Kwon, Tae-Hun Kim Introduction Long coronavirus disease (COVID) poses a significant...

The efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID: a Systematic Review and meta-analysis Gangqiang Sun, Ke Lin, Jingwen Ai, Wenhong Zhang Abstract Background: Whether treatment during acute COVID results in protective...

Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection Key Points Question What is the efficacy of 15 days of nirmatrelvir-ritonavir for improving select symptoms of postacute sequelae of SARS-CoV-2 infection (PASC)? Findings This randomized clinical...

Effectiveness of Nirmatrelvir–Ritonavir Against the Development of Post–COVID-19 Conditions Among U.S. Veterans Background: COVID-19 has been linked to the development of many post–COVID-19 conditions (PCCs) after acute infection. Limited information is available on the effectiveness of oral...

A team in Germany is planning to launch a trial with the drug IMU-838 trial for Long Covid. Currently there aren’t too many details on the trial, however Maria Vehreschild of the Universitätsklinikum Frankfurt has given some details in this talk www.vimeo.com/873993707/description (from 32:30...

A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes Sanderson, Theo; Hisner, Ryan; Donovan-Banfield, I’ah; Hartman, Hassan; Løchen, Alessandra; Peacock, Thomas P.; Ruis, Christopher Molnupiravir, an antiviral medication that has been widely used against SARS-CoV-2, acts...

Nirmatrelvir/ritonavir and risk of long COVID symptoms: A retrospective cohort study We conducted a retrospective cohort study to assess whether treatment with nirmatrelvir/ritonavir was associated with a reduced risk of long COVID. We enrolled 500 adults with confirmed SARS-CoV-2 who were...

The actual study start date was March 2023, the estimated primary end date was 1 June 2023 and the estimated study completion date is 1 October 2023. Clinical Trials link: https://clinicaltrials.gov/ct2/show/NCT05813587?term=Meplazumab&draw=2&rank=8 Randomized, double-blind...

imPROving Quality of LIFe In the Long COVID Patient (PROLIFIC) https://clinicaltrials.gov/ct2/show/NCT05823896 Petter Brodin Karolinska Institutet, Sweden "Brief Summary: The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with...

Key Points Question Is treatment with nirmatrelvir in the acute phase of SARS-CoV-2 infection associated with a lower risk of post–COVID-19 condition (PCC)? Findings In this cohort study of 281 793 people with SARS-CoV-2 infection who had at least 1 risk factor for progression to severe...

https://www.frontiersin.org/articles/10.3389/fmed.2022.1003103/full Introduction: Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC) in ∼30% of all infected individuals. Here, we present a case of PASC in a patient with rheumatoid arthritis characterized by viral persistence in...

Abstract Background There is a paucity of knowledge on the long-term outcome in patients diagnosed with COVID-19. We describe a cohort of patients with a constellation of symptoms occurring four weeks after diagnosis causing different degrees of reduced functional capacity. Although different...

https://www.pharmiweb.com/press-release/2021-05-07/virios-therapeutics-to-present-at-the-benzinga-global-small-cap-conference

Split from Mail Online: Why many of those struck by Long Covid may be suffering from glandular fever: Blood tests on some patients are coming back positive for ‘ Here is a link from ME-pedia on the use use of valaciclovir. The study that is mentioned on this page showed that, " Improvement...

There are at least eight herpes virus variants that infect humans. These include: Human herpes virus 1 (HHV1) is also known as herpes simplex virus 1 (HSV1). Human herpes virus 2 (HHV2) is also called herpes simplex virus 2 (HSV2). Human herpes virus 3 (HHV3) is also called varicella-zoster...