Long-COVID Postural Tachycardia Syndrome: A deep phenotyping study
Nicholas W Larsen; Jannika V Machnik; Jordan Seliger; Ruba Shaik; Christopher H Gibbons; Paul J Utz; Maarten G Lansberg; Srikanth Muppidi; Safwan Jaradeh; Mitchell G Miglis
BACKGROUND
Postural tachycardia syndrome (POTS) has...
Altered amyloid plasma profile in patients with disabling headaches after SARS-CoV-2 infection and vaccination
Anne Hege Aamodt; Thor Ueland; Marion Boldingh; Burcu Ella Bezgal; Mari Argren; Cecilia Adele Dunne; Kari Otterdal; Ida Gregersen; Vigdis Bjerkeli; Annika Elisabet Michelsen; Andreas...
Abstract
The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) was used to...
Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity
Oana Sanislav; Rina Tetaj; Metali; Julian Ratcliffe; William Phillips; Annaleise R. Klein; Ashish Sethi; Jiangtao Zhou; Raffaele Mezzenga; Sina S. Saxer; Mirren Charnley; Sarah J...
Reduction of hemagglutination induced by a SARS-CoV-2 spike protein fragment using an amyloid-binding benzothiazole amphiphile
Li, Meihan; Castro Lingl, Sascha; Yang, Jerry
COVID-19 infection is associated with a variety of vascular occlusive morbidities. However, a comprehensive understanding...
Fibrinaloid Microclots and Atrial Fibrillation
Kell, Douglas B.; Lip, Gregory Y. H.; Pretorius, Etheresia
Atrial fibrillation (AF) is a comorbidity of a variety of other chronic, inflammatory diseases for which fibrinaloid microclots are a known accompaniment (and in some cases, a cause, with a...
An amyloidogenic fragment of the SARS CoV-2 envelope protein promotes serum amyloid A misfolding and fibrillization
Asal Nady; Sean E Reichheld; Simon Sharpe
SARS CoV-2 infection can affect a surprising number of organs in the body and cause symptoms such as abnormal blood coagulation...
Blood Markers Show Neural Consequences of LongCOVID-19
Tang, Norina; Kido, Tatsuo; Shi, Jian; McCafferty, Erin; Ford, Judith M.; Dal Bon, Kaitlyn; Pulliam, Lynn
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists throughout the world with over 65 million registered cases of...
Amyloid-Fibrinogen Aggregates Microclots Predict Risks of Disseminated Intravascular Coagulation and Mortality
Schofield, Jeremy; Abrams, Simon Timothy; Jenkins, Rosalind; Lane, Steven; Wang, Guozheng; Toh, Cheng-Hock
Microclots have been associated with various conditions, including post-acute...
Plasma proteomic evidence for increased Alzheimer's disease-related brain pathology after SARS-CoV-2 infection
Eugene P Duff; Henrik Zetterberg; Amanda Heslegrave; Abbas Dehghan; Paul Elliott; Naomi Allen; Heiko Runz; Rhiannon Laban; Elena Veleva; Christopher D Whelan; Benjamin B Sun; Paul M...
Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation
Lee EY; Srinivasan Y; de Anda J; Nicastro LK; Tükel Ç; Wong GCL;
Pathological self-assembly is a concept that is classically...
ThT 101: a primer on the use of thioflavin T to investigate amyloid formation
Kirsten Gade Malmos; Luis M. Blancas-Mejia; Benedikt Weber; Johannes Buchner; Marina Ramirez-Alvarado; Hironobu Naiki; Daniel Otzen
Thioflavin T (ThT) has been widely used to investigate amyloid formation since 1989...
Muscle Abnormalities Contribute to Post-Exertional Malaise in Long COVID
A poster presentation of the very soon to be published work by Rob Wüsts team has been uploaded to Twitter.
Paper now published, see post #8
SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein
Chesney, Andrew D.; Maiti, Buddhadev; Hansmann, Ulrich H. E.
Parkinson’s Disease is accompanied by presence of amyloids in the brain formed of α-synuclein chains. Correlation between COVID-19 and the onset of Parkinson’s...
Abstract
Background
Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease (COVID-19) and Long COVID/Post-Acute Sequelae of COVID-19 (PASC), might form a suitable set of foci for the clinical...
Rapidly evolving Creutzfeldt–Jakob disease in COVID-19: from early status epilepticus to fatal outcome
Olivo, S., Furlanis, G., Buoite Stella, A. et al.
We report the case of a 70-year-old man coming to our attention for new onset refractory status epilepticus (NORSE) in a rapidly evolving CJD...
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