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They both have a synergistic anti-glutamate effect. Gabapentin impairs glutamate release in part through its function as a voltage gated calcium channel inhibitor. Memantine complements this reduction in glutamate signalling through antagonism of one of the key glutamate receptors...

Hi, I just thought I would share my experience with regard to how I manage my neuroexcitotoxicity. I take memantine 30mgs daily with gabapentin 1200mgs 3 x daily. I'm surprised not more people seem to have explored these management strategies. I also take salinated water 2 litres daily. Does...