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  1. energyoverload

    energyoverload Established Member

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    Hi,

    I just thought I would share my experience with regard to how I manage my neuroexcitotoxicity. I take memantine 30mgs daily with gabapentin 1200mgs 3 x daily. I'm surprised not more people seem to have explored these management strategies. I also take salinated water 2 litres daily.

    Does anyone else use a similar daily coping strategy?

    energy.
     
    Allele likes this.
  2. Alvin

    Alvin Senior Member (Voting Rights)

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    Interesting, an antidementia and epilepsy drug combination
    Out of curiosity how did you come to these particular drugs?
     
    Last edited: May 20, 2018
  3. energyoverload

    energyoverload Established Member

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    They both have a synergistic anti-glutamate effect. Gabapentin impairs glutamate release in part through its function as a voltage gated calcium channel inhibitor. Memantine complements this reduction in glutamate signalling through antagonism of one of the key glutamate receptors (n-methyl-d-aspartate). I decided to try adding the two together because of this rationale, so some was acquired. Memantine can be prescribed off label of course.

    I only bring this up because, I have tried so many different protocols and supplements including the methylation protocol, and by far, although this is not 'fixing' anything, in my case this combination has a far greater effect than anything else I have come across COQ10, ubiquinol, Acetyl l carnitine to name but a few.

    I also have been on Rituximab which unfortunately did not work in my case..
     
  4. Alvin

    Alvin Senior Member (Voting Rights)

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    Interesting.
    What made you target glutamate?
    Sorry to hear about Rituximab not working for you :(
     
    Trish likes this.
  5. adreno

    adreno Senior Member (Voting Rights)

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    I have tried memantine. But just 5mg makes me completely brain dead.
     
  6. Creachur

    Creachur Established Member

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    I have long been interested in trying memantine but I always seem to have too much going on and I recall it needs a week or two to establish itself.
     
  7. Keebird

    Keebird Established Member (Voting Rights)

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    Glad to hear that you found something that helps. I was prescribed memantine for migraines and had a horrible experience with it. It made me feel disconnected, depersonalized, foggier than usual, and gave me vertigo. I don’t usually have severe reactions to meds so was surprised. I gave it a 6 week trial and the side effects never got better. Interested to see if it starts being prescribed more commonly for ME/CFS and how folks respond to it.
     

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