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  1. ellesa

    United Kingdom: Action for ME's PRIME project - research infrastructure

    Interview by David Tuller with Chris Ponting Annual conference, 4 workshops a year. Half a dozen academics co-leading. Project reaching out to industry. A project manager who will seek new links with industry, academia and international projects.
  2. ellesa

    Keystone symposium Long COVID and Other Post-Acute Infection Syndromes August 10-13 2025

    Maureen Hanson is presenting, the title is tantalising
  3. ellesa

    Learning about the immune system

    I've found these books to be relatively friendly and helped me get a very general map of the landscape without actively making my brain learn - An Elegant Defence https://www.goodreads.com/book/show/41806641-an-elegant-defense A Cure Within...
  4. ellesa

    UK NIHR: Post-acute infection syndromes, including long COVID and ME/CFS funding for feasibility of setting up platform for testing treatments, 2025

    I wonder if that was listed to include things like tVNS. I noticed a specific call-out to discourage exercise and similar therapies, which is encouraging.
  5. ellesa

    Video: Figuring Out Long COVID - with Emma Wall, Research Fellow at the Crick, 2025

    Emma Wall said something in the video along the lines of the first round of drugs in STIMULATE ICP being based on 'Toby and I doing some beard stroking in 2021'. There appears to be an attempt to be more targeted in the second round. She also mentions collaborating with PHOSP which has...
  6. ellesa

    Video: Figuring Out Long COVID - with Emma Wall, Research Fellow at the Crick, 2025

    It doesn't go into much detail so probably not worth going back to, but she does mention that STIMULATE ICP will be doing a second round of trials and they are planning that now ish Going by the other videos on that channel the talk series seems to be fashionable memes in general
  7. ellesa

    Video: Figuring Out Long COVID - with Emma Wall, Research Fellow at the Crick, 2025

    The first half is a bit of an intro for the general audience, in the second half she walks through the work her group actually does
  8. ellesa

    Mapping off-target effects of small molecule drugs

    This may be of interest to this forum - a Focused Research Organisation called EvE Bio is setting out to map all the unintended targets of small-molecule drugs. They have a five year target and started last year, with four data releases so far https://data.evebio.org/. They were funded by...
  9. ellesa

    Video: Figuring Out Long COVID - with Emma Wall, Research Fellow at the Crick, 2025

    Emma Wall has a presentation at Keystone next month titled 'An Innate Inflammatory Signature Is Consistently Enriched in the Plasma of Adults Living with Long COVID Across all Clinical Symptom Groups' https://www.keystonesymposia.org/conferences/conference-listing/meeting/onpage-program/F12026
  10. ellesa

    Open source AI tool for biomedical research

    I saw this shared on twitter, a Stanford open source AI tool specifically for biomedical research It is free but requires contacting the team for access https://biomni.stanford.edu/about The tweet read
  11. ellesa

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    Ok that makes sense, thank you! Apologies for the many questions but since everybody talks about inflammation in ME/CFS all the time, I would like to understand a little bit about what you mean - my understanding is that inflammation is immune activity that results in a physical response...
  12. ellesa

    USA: The RECOVER Initiative - Long Covid research

    They have uploaded this timeline recapping major activities. I believe agent review for the Neurological working group has been completed, one of the patient representatives who is a neurologist and mother to a child with severe Long Covid posted an update on twitter a few weeks ago. Drugs...
  13. ellesa

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    Thank you, so far what I have learned about immunology is that there is not A -> B -> C, but a combination of {A, B, C, D, E} that needs to happen at the right time for {G, H, I} to happen. And that C, D, E, H or I are not well understood or discovered yet. So is it kind of like everyone...
  14. ellesa

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    Apologies if this is not the right place to ask this, but I am wondering if some recent work in LC aligns with the hypothesis. I am only at the hot dogs and buns stage of learning immunology so I can't do much more than notice when the same words are occasionally repeated, without understanding...
  15. ellesa

    The Concept of ME/CFS

    Thank you, that makes sense. I did read the first draft that was posted but I was a little foggy at the time (and always?) Occasionally I try and get clear in my head a definition of ME that can fit in a half tweet length or so, for the rather common conversation with LC patients on twitter who...
  16. ellesa

    The Concept of ME/CFS

    Apologies if this is in the wrong place, and I have skimmed the thread but it is quite long so I have not absorbed all of it. I saw some comments re: ME/CFS as a concept being distinct and new from both ME and CFS. I was curious about this since the description that best matches my physical...
  17. ellesa

    Significance of unrefreshing sleep in IOM diagnostic guidelines

    Several years late but I came here wondering the same thing; I am housebound, with PEM (though no flu-like symptoms with PEM), OI and cognitive issues, but wake up most mornings with my brain feeling good, and with no physical feelings of fatigue, weakness or malaise. In the first year or so I...
  18. ellesa

    Thesis Characterising the Electrophysiological Properties of Cells in Health and Disease [on ME/CFS], 2024, Clarke

    A difference was observed between cohorts in the percentage change in ζ-potential (%) between 1.5-hour hyperosmotic NaCl incubation and 1.5-hour physiological incubation
  19. ellesa

    Upadacitinib (rinvoq)--could it reduce fatigue in ME/CFS?

    I've just posted this grant https://www.s4me.info/threads/niaid-r01-grant-to-study-persistent-lung-injury-in-long-covid.44851/ Sounds like this team may also be studying JAK inhibitors?
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