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I appreciate and applaud yr efforts! (And my ego will surely survive to fight another day!) That's what I wanted to hear! Fortunately, I am not yet fully mummified. I really appreciate the reply. My life went completely off the rails a couple years ago. I haven't followed the research or been...

I apologize for my unhinged speculation. I'm more of an idiot than pathologist. Still... I'm going to belabor my wild pathologist-unsupported hypothesis a bit further. I stopped recovering from excercize normally in about 1983. And developed a slew of other problems, which I later began...

I think a better analogy is that the petrol tank is full, but the petrol filter has become dirty, allowing only a trickle of petrol to get through. It's not an on/off situation - rather a reduced rate of flow. Or, imagine that the injectors for each engine cylinder have their own filters -...

Paths to treatment seem attainable. What's the holdup on drugs like suramin? "... most cases of chronic disease are not caused by an active threat... [They] result from incomplete healing and recovery after a threat or injury has passed...[an] inability to actively extinguish the... (metabolic...

Here's a thoughtful and seemingly informed breakdown of Prusty's short presentation in Berlin from aure @maureviv on Twitter:

"The theory and practice of medicine mandates that subjective complaint guide the modality and interpretation of objective evidence." I'd settle for gathering objective evidence.

The previously-mentioned Atlantic article, "One of Long COVID’s Worst Symptoms Is Also Its Most Misunderstood", offers some of the best descriptions of my present cognitive issues.

Neuroinflammatory model, as published by Marvel Entertainment: Virus* make brain angry! Brain SMASH! Okay, now give brain funding and brain fill in blanks for you. *: or bacteria, or mold, or stress, or a really bad stumble.

I think you mean corroborates, not collaborates. Verb: confirm or give support to (a statement, theory, or finding). 3rd person present: corroborates; past tense: corroborated; past participle: corroborated; gerund or present participle: corroborating "the witness had corroborated the boy's...

Wait - I developed ME from exploring sexually dimorphic pathways? I thought that's what university was for!

I'm bitter as hell - there is no question about that. And my comments reflect that. I don't wish to drag this discussion out, but I'll add two more things. I agree with Hutan. There have been countless hypotheses proposing neuroinflammation. Each one involves an Abracadabra hand wave at the...

"Then, a brain-signature for both ME/CFS (and PCFS) might even become attainable, within the next decade, perhaps." F U.

Another cocktail napkin full of wild speculation? Sure, just put it on the shelf over there with the other 127 hypotheses that no one has the interest or funding to pursue. Seriously, what is the point of publishing any more hypotheses? Unless, of course, you offer a testable mechanism that...

Well, no - not at 70dB, Michelle. But have you tried 100 dB? You've got to get over that 90 dB hump to really get the brain juice flowing.

Yeah, I've seen four neurologists in the USA in the last ten years. And two psychologists. And three psychiatrists. [Edit: no, five, including psychiatric nurses.] And five GPs (or PCPs). And about ten social workers. None of them care. Literally. I don't know what "brain charity" is; I'll try...

I've suffered from something like ME for 40 years now. About 10 years ago, my episodes of brain fog were getting worse and more frequent. Around that time, I experienced an episode of winding up at a (familiar and frequently visited) store that is a one-hour drive away, with no recollection of...

Done.

ETA links and winks. Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation, 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995113/ Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of...

I went down a rabbit hole of research on this guy and related studies. I eventually ended up at the 2022 paper, Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance, where they report this good news for headbangers: "Another study...

So, nothing ME/CFS here. And the chemistry is far beyond my understanding. However, there are a few reasons this seems important to me: 1) new understanding of the role of mitochondrial magnesium; 2) and its relationship to calcium; 3) intracellular Ca overload plays a significant role in the...