That seems to be often the case. They are 'expressed' (i.e. make RNAs) very specifically in certain cells. Only if you could sample the cells...
Yes, thinking back to information sheets I have written this is hopelessly inadequate. I always explained what the drug was supposed to do and why...
I think that statement and the fact that the neurological classification was a mistake are correct. There are no measurable abnormalities that we...
Afraid not.
This is a complete joke. I remember a departmental journal club around 1995, before adalimumab was licensed or even had that name where we...
It sounds encouraging. I have looked through the paper rather quickly and cannot find any account of what the genes puled out actually are. I...
The best thing I can think of is a dose response study, with 3 or 4 doses (9-12 cases). The lowest dose effectively acts as a control. You would...
No idea really but not this sort of self-fulfilling open trial.
Except that they are not effects, merely observed changes. Nobody knows what caused them. I wouldn't want to see any more of this without (a) a...
Yes to both. Almost as barbaric as trepanning or blood letting.
Yes and why they think it might help. They could provide an explanation for why patients should be interested for S4ME.
Frankly, if I had had to think about all that when I was on an ethics committee for ten years I would have resigned overnight. This is the problem...
You could ask them for some information - real information.
Whenever you get a group of people like this with bee's nests in the pants of their hobby horses you will get a Lord of the Rings/Harry Potter...
It might do. But I have now given up offering to review grant applications, unless I think they are really important ME/CFS ones, because I cannot...
It would be up to the trialists to ensure safety. Giving patients that sort of information would not be valid 'informing' because they could not...
The basic problem is that if ethics committees are not applying ethical principles it is either because they do not understand or because they, or...
Do you mean guidelines for trial practice? I am doubtful that any attempt to target protocols and guidelines will have any impact. Protocols and...
I like this idea too. It might seem a bit technical but, as several members have said, once you get your head around the reasons they aren't too...
I agree. The whole thing is underwhelming. 'High profile' biomedical science seems increasingly just to be re-arranging the verbal deckchairs on...
Separate names with a comma.
