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I listened to a lot of the presentations on infections and fungi and it seemed to be all speculation and suggestions about what they might do in the future without much critical analysis.

Nice find.

I do wish someone would do a WGS analysis of early onset (<13y 0r <15y) ME/CCFS.

Ah. I had not seen that. I think I now understand your previous comment about the low levels being related by some common artifactual influence. The apparent absence of cortisol in CSF makes no real sense as consequence of depleted CRH cells unless these cases are unusual instances of...

Remarkable. Olfactory pathways connect to nucleus acccumbens and frontal regions.

Did you mean that? I thought these data were CRH cells in brain rather than cortisol?

If only funds spent on this sort of thing could be spent on the good research that we know needs to be done.

Only where there is no flow. Low systemic blood pressure would reduce the rate of nutrient/oxygen bearing blood flow through brain capillaries and that is why people feel faint when they stand up too quick normally. The blood volume in brain need not change, just how fast it is moving through...

I wonder if those numbers reflect the Severe video being restricted to professionals. Maybe very few of any of them have been seen by professionals. Edit: looks from the figures to be rather that way.

I have had a read through this. It provides some citations and findings about water flux but there seems to be a serious lack of understanding of what the results imply. Water can move in tissues in three ways: 1. Convective flow. This is where water molecules all move together as in coming out...

I think it is a pity that orgniasations like MERUK put out articles on studies like this without any evaluation. It must raise an awful lot of hares with patients who are not aware of just how 'science' is junk these days.

I think the answer is attention to the detail of the pharmacodynamics of your test drug. So often these trials follow standard protocols that miss the answer.

Lupus is extremely difficult to do trials on because of the fluctuating course.

It's an interesting idea. My guess is that the pathways linking one to the other operate more or less in real time day be day so that you won't get much differential observing over weeks but that might be wrong.

Indeed. The issue of female preponderance continues to puzzle me, because the mechanism of female traits is so complex. It seems that it is just the absence of a Y chromosome that encodes for general female habitus in the newborn but Turner's syndrome (XO) shows that you need two Xs (with...

Agree. I wonder how it might relate to HHV6 etc. which Jackie Cliff is interested in, although the reservoir seems to be very different.

I had a further scan through the PDF, which I got through the DOI. They talk of an equilibrium rather than directional flow. This suggests a misunderstanding. The key point from Levick is that there is a far-from-equilibrium oncotic state the needs maintaining. That might look like 'flow...

Thanks for finding that. This is very much consistent with what I concluded on the other glymphatic thread. What is intriguing is that they do not seem to have identified the overarching reason why CSF has to exist in the context of the unique pressure gradients across brain blood vessels - the...

We might have a problem that a brain bank may not look at spinal cord. There was no mention of dorsal root ganglia in the CRH neuron study as far as I know and maybe they didn't look.

I have been saying for about a year that I thought progress would soon be made, including suggesting that we might be further ahead by Christmas 2025. I am not disappointed. DecodeME has brought things into focus in a completely new way. I am prepared to predict that there will probably be...