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But is it? My impression is that data so far suggest that five people and maybe a dog have done it. I find it hard to believe that this sort of module is used for teaching on al diseases? If I had to work through this sort of thing for every disease that was going to come along I would resign...

I am not sure why we should think it would be either. The applicant mention that some people with ME/CFS say they take longer to get better from colds and flu. But we have two decades of studies of immune cells in ME/CFS not showing very much. I would like to see more focus. And even if people...

Me too.

It is maybe worth noting that the presence of CD4 T cells does not mean anything very specific. T cells patrol tissues and hang about if the tissue is not quite healthy, for whatever reason. rather as macrophages do. CD4 cells outnumber CD8 in at least some other situations. But it is useful to...

Jo Cambridge is the one real Immunologist here. She is emeritus professor, probably of immunology. She is not a rheumatologist but worked alongside me in a department of rheumatology at UCL. I am emeritus professor in connective tissue medicine and was a clinical physician/rheumatologist...

I think the problem with the theory is that exposure to most infections is there right from primary school and exposure to EBV when kids get romantic is a bit too late for the first peak. Linking the first peak to EBV is an obvious possibility that the authors were well aware of. I dont know if...

Something I have been wondering about is whether susceptibility might cluster around a regulatory shift that works a bit like a software update. We are very used to the idea that in other types of animals complete software rewrites are obvious. The classic ones are insects undergoing...

This is how I understood things when going through with Audrey a while back. The difficult thing to get a handle on I think is that we should not expect Gaussian peaks for age profiles for a disease. It would make more sense to have more complex profiles, still based in inverse exponentials (as...

It does not have to be vestibular. You work that out by going through all the other neurological signs. But a positive Romberg test (which is this) is abnormal and usually has an identifiable explanation. Of course, someone with ME/CFS with OI will have OI with their eyes open so the test is...

If it is just POT it makes perfect sense. Postural tachycardia is not necessarily associated with any orthostatic intolerance. The emergence of unsteadiness when closing eyes is an important and pretty reliable neurological sign indicating that the person is relying more on vision and...

So a wastebasket of every uncle Tom Cobley disease you can think of.

I cannot find any information about the 'autoimmune diseases' they included. They seem to be in a supplementary table not available. The lack of any up front information makes me think the results are pretty uninterpretable. As far as I am concerned all autoimmune diseases have autoantibodies s...

Without going through a whole lot of potentially confounding reasons for association I suspect not much. It would be interesting if some autoimmune disease predisposed and others protected perhaps. I am not sure what 'primary autoantibody-associated disease' means.

I would be surprised if changes in microglia shape would be identifiable with MRI methods. Even a stellate microglia is very small.

Cerebral lupus is a situation where brain water content increases, apparently in response to antibody complexes or possibly anti-neuronal antibodies getting into brain. Intracranial pressure rises and blood pressure rises. A characteristic sign of impending cerebral lupus crisis is that the...

That would be my working explanation. As to why, that is the mystery. It happens in cerebral lupus too. The two situations may be quite different, but maybe not so much.

Perhaps it has something to do with the various hints at lipids like sphingomyelins that we have seen from metabolomics etc.

Wasn't that an imaging study that none of us could interpret clearly and which needed some follow up work to make sense of?

I was definitely under the impression that his consultant post was in rehab with a cardiac emphasis. The positivity is around knowing stuff. So any suggestion that we don't know stuff is billed as 'negative'. The MEA view is that patients shuld be told stories about what we 'know' about their...

As far as I know all mitochondrial test used on people with ME/CFS are discredited. We have no reliable evidence of mitochondrial abnormalities. I don't know what RNA studies you are referring to but I have not seen anything consistently abnormal. 'Dysregulated' is nearly always an unjustified...