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  1. J

    Aripiprazole - Abilify

    Yes—move if you like.
  2. J

    Aripiprazole - Abilify

    Thread “…a combo of 20 mg Amitriptyline and 1 mg Risperidone has brought them from severe to moderate. “
  3. J

    News from Germany

    “In the Bundesliga match between @tsghoffenheim and @1FSVMainz05, players and referees gathered on the pitch before kickoff with a clear message: CURE ME/CFS!Another powerful and successful campaign by http://EmptyStands.me “ If the match is in Germany, why is the sign in English?
  4. J

    Ozempic, tirzepatide and other GLP-1RAs - impact on ME/CFS

    Why are you taking it if your BMI is 19???
  5. J

    Preprint Spironolactone for ME/CFS in a Patient Homozygous for rs5522 (I180V): A Case Report, 2026, Donnellan et al

    OK, but is the horse taking Spironolactone?—seems like that is the important question.
  6. J

    Using AI tools for medical questions, as a patient - Discussion

    When Doctors Couldn’t Solve Their Medical Mysteries, They Turned to A.I.—discusses ME/CFS https://www.nytimes.com/2026/04/02/well/live/ai-illness-claude-chatgpt.html?unlocked_article_code=1.X1A.mzmz.Rd9qXcpcubDc&smid=nytcore-ios-share Some women with complex chronic illnesses are using...
  7. J

    Intravenous immunoglobulin treatment for long COVID: a case report of clinical and immunological findings 2026 Camici et al

    Any help with the question in the post above? @Jonathan Edwards @jnmaciuch Thanks.
  8. J

    Intravenous immunoglobulin treatment for long COVID: a case report of clinical and immunological findings 2026 Camici et al

    Summary A previously healthy 39-year-old man developed highly symptomatic post-COVID-19 condition (also known as long COVID) marked by cognitive dysfunction, disabling fatigue, and autonomic symptoms unresponsive to multiple multidisciplinary interventions. Given the presence of markedly...
  9. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    https://www.cdilabs.com/company/leadership https://www.cancergrandchallenges.org/tyler-hulett https://finance.yahoo.com/news/cdi-labs-dr-tyler-hulett-113000242.html He is an autoantibody specialist.
  10. J

    Open USA: Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms [LC] (REVERSE-LC)

    “i’m in a drug study for Baricitinib (REVERSE LC- clinical research trial) and it helps with this! [brain inflammation] it’s been life changing to not have my immune system at its own throat constantly. the study is still open for enrollment i believe!” Again is this person sure she is not...
  11. J

    Trial Report The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID, 2026, Reis et al

    Probably more important to do a trial, even smallish, for Abilify/rexulti/vraylar (diff mechanism from fluv.) which should yield a higher positive effect than the effect fluvoxamine demonstrated here.
  12. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    “Fluge & Mella doing great work on daratumumab for ME/CFS - thank you to @ryan_czm for introducing me.” Shout out to @ryanc97 Nice work!!! :trophy@
  13. J

    Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma 2025 Costa et al.

    “Did the daratumumab *just* destroy the myeloma - or did it *also* knock out a T-cell suppressing autoantibody? Daratumumab depletes long-lived plasma cells via CD38 & potentially-harmful immune-altering autoantibodies - not just the cancer! @casanova_lab”
  14. J

    Daratumumab, isatuximab (CD38 drugs)

    Ok I’ll post it there.
  15. J

    Eli Lilly to buy Centessa Pharma in $6.3 billion deal

    https://www.biospace.com/deals/lilly-wakes-up-sleep-market-with-6-3b-centessa-buy-to-challenge-takeda This drug delays sleep. Interesting…. “In April 2025, Centessa released Phase 1 datashowing that a 5-mg oral dose of cleminorexton delayed sleep by an average of 37.9 minutes compared to 15.3...
  16. J

    Eli Lilly to buy Centessa Pharma in $6.3 billion deal

    https://finance.yahoo.com/sectors/healthcare/articles/eli-lilly-buy-centessa-pharma-105318456.html The acquisition gives Lilly ownership of Centessa’s orexin receptor 2 (OX2R) agonist pipeline, including cleminorexton, described as a “potential best-in-class therapeutic” for sleep-wake...
  17. J

    Daratumumab, isatuximab (CD38 drugs)

    “Did the daratumumab *just* destroy the myeloma - or did it *also* knock out a T-cell suppressing autoantibody? Daratumumab depletes long-lived plasma cells via CD38 & potentially-harmful immune-altering autoantibodies - not just the cancer! @casanova_lab “
  18. J

    Trial Report The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID, 2026, Reis et al

    Participants were randomly assigned to fluvoxamine (100 mg twice daily). This is a middle range dose for depression. It would be good if further research could do a dose/response study to see if lower dosages could be effective.
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