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  1. Hutan

    Long-term Prognosis at 1.5 years after Infection with Wild-type strain of SARS-CoV-2 and Alpha, Delta, as well as Omicron Variants, 2023, Agergaard et

    Post COVID Clinic at Aarhus University Hospital (AUH) There are a lot of typos that make this paper rather difficult to read. e.g. (Ref 9 says "The available data suggest that the infection with the Omicron variant results in fewer long-COVID symptoms compared to previous variants" and...
  2. Hutan

    Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19, 2023, Rousseau+

    The reported persisting symptoms seem quite odd - the percentages reporting each were mostly much lower than I'm used to seeing in Long Covid cohorts. 49.7% reported fatigue; 33.1% reported breathlessness; 20.1% reported joint pain. 41% reported 'anxiety and depression'; loss of taste and smell...
  3. Hutan

    Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19, 2023, Rousseau+

    The control cohort is also post-infection. The PCC cohort here has fewer people over 65 (18%) than the control cohort (25%). Also 59% female versus only 46% female in the control cohort Still a high hospitalisation rate compared to the controls (58% versus 34%), although it is claimed that 55%...
  4. Hutan

    Review Prevalence of sleep disturbances in patients with LC assessed by standardised questionnaires and diagnostic criteria... 2023 Chinvararak and Chalder

    Indeed. That statement is coming from a woman who invented a scale asking people whether a symptom now is worse or better than what it was when they were well. If it really is impossible to know whether sleep problems pre-dated infection, then it is also impossible to know, simply by asking...
  5. Hutan

    Guardian — Health anxiety can be all-consuming. Accepting uncertainty is an important step

    I guess there are lots of reasons. It's increasingly hard to see the same GP when making appointments - practices tend to be larger with a big roster of doctors and an even bigger number of patients. Without that continuity of care, it's easier for doctors to dehumanise their patients...
  6. Hutan

    The effects of a structured communication tool in patients with medically unexplained physical symptoms: a cluster randomized trial 2023 Abrahamsen

    Perhaps here is another Freudian slip, from the 'Added value of this study' summary: Rather than 'comprising', this study 'compromises' both patients and GPs 'Compromising' definitions: (of information or a situation) revealing an embarrassing or incriminating secret about someone. e.g...
  7. Hutan

    Guardian — Health anxiety can be all-consuming. Accepting uncertainty is an important step

    Oh, the irony. The labelling of many people with 'health anxiety' is surely partly the result of doctors feeling uncomfortable with a situation where they can't otherwise identify a cause of the patient's symptoms. Feeling that they must know everything and always get things right, 'health...
  8. Hutan

    Complement dysregulation is a predictive and therapeutically amenable feature of long COVID, 2023, Morgan et al

    The mismatch on BMI could definitely be an issue: The complement system is dysfunctional in metabolic disease: Evidences in plasma and adipose tissue from obese and insulin resistant subjects, 2019, Moreno-Navarette et al For example the Factor D finding could have been affected by the...
  9. Hutan

    Complement dysregulation is a predictive and therapeutically amenable feature of long COVID, 2023, Morgan et al

    Figure 5 is a correlogram. 5a is for all of the substances tested, for the controls, and 5b is for the cases. (I don't understand why these two correlograms weren't combined - what is the point of duplicating the same data above and below the diagonal line? I mean, you could put the case data...
  10. Hutan

    Complement dysregulation is a predictive and therapeutically amenable feature of long COVID, 2023, Morgan et al

    Yes, good sample size, healthy controls had also had Covid-19. Figure 1 - Dot plots for the 6 complement activation products, plasma concentrations. Overlaps, but some great P values. Long covid on the left. They investigated levels of complement components and regulators too, and again...
  11. Hutan

    Complement dysregulation is a predictive and therapeutically amenable feature of long COVID, 2023, Morgan et al

    This sounds interesting. It's too late in the day for me to read it today, but I look forward to hearing more e.g. sample size, how the individual complement proteins compared, whether any of the findings have also been found in ME/CFS.
  12. Hutan

    UK Long COVID Service Evaluation and Forward Planning, 2023, Bath, Swindon and Wiltshire

    I'm not sure that it does prove that harm to patients is intended. I think many health professionals involved in this truly believe that they are helping these inadequate people with their low self-efficacy to become better versions of themselves and recover. The fact that providing this...
  13. Hutan

    Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS Spike Protein in Human Cell Culture, 2023, Aguida +

    Almost as if humans had evolved to live in an environment with natural sunlight... I'm not sure if our problem is ROS and/or things to do with NO, but there are hints that both are affected by sunlight. I think a study of people with severe ME/CFS - providing exposure to morning sun or an...
  14. Hutan

    What's the main MECFS org in Canada?

    We have this thread, which has the two organisations that DokaGirl mentioned and a couple of others: ME/CFS and Long Covid charities/ organisations - International and National There's a link there to a thread with Canadian regional organisations.
  15. Hutan

    Are Sexual Assaults Related to Functional Somatic Disorders? A Cross-Sectional Study 2023 Jacobsen et al

    This problem alone invalidates the study. People who are willing to bear the label 'Functional Disorder' are much more likely to buy into the idea of past trauma being responsible for their current physical health. If you have persistent symptoms and you've had a fairly trouble-free life, you...
  16. Hutan

    ME/CFS and Long Covid charities/ organisations - International and National

    Thank you @Suffolkres, great news. I'll add LocalME to both our UK national and regional organisations list, and we'll also add LocalME to the open letter supporter list. How great that 52 small organisations are so well organised, and that the UK has the 52 organisations.
  17. Hutan

    Effectiveness of psychosomatic therapy for patients with persistent somatic symptoms: Results from the CORPUS... 2023 Wortman et al

    As Andy said, the treatment is pretty much CBT and GET. I think, there have been a lot of BPS trials, perhaps even most, where it is not made clear to the participants that such treatments are aiming to correct psychosomaticism. It would be great to get hold of the information pack and hear...
  18. Hutan

    Occupational Therapists for ME (OTs for ME)

    Oh that sounds sad. I think a lot of us would identify with coming to a point where we have to let go of our past profession and the aspirations and plans we had tied to that. For those with expensive annual practising certificates and other professional requirements, I imagine that point is...
  19. Hutan

    Effectiveness of psychosomatic therapy for patients with persistent somatic symptoms: Results from the CORPUS... 2023 Wortman et al

    Version of a comment posted in response to Dave's article. The paper said:”Due to our selection procedure we may have included patients who did not always expect a psychosomatic approach.” @dave30th said: “Are the investigators suggesting that participants were too stupid to read or understand...
  20. Hutan

    ME/CFS and Long Covid charities/ organisations - International and National

    Welcome to the forum @Long Covid SOS! It's great to have you here. Certainly, adding you now. Done
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