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George Monbiot: "I really hope this isn't about ME/CFS - again. The "silencing" story around this illness has a. been inflated beyond recognition b. been used for the past 13 years to protect bad science from effective scrutiny...

Pot, kettle. There is so much irony in that piece. They really don't seem to see that the people they support have a hypothesis at least as poorly founded as Kell et al, and have imposed a treatment regime on the very people that these authors claim to be concerned about. I am interested...

suicide rate per 100,000 people

From ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity

An interesting watch. Related to this, an Icelandic doctor who has a son with ME/CFS has joined the board of IACFSME. More here: International: IACFS/ME - International Association for CFS/ME, IACFSME

From an email update: a new board member for IACFSME: He sounds good, he has a son with ME/CFS. " Dr. Sigurdsson is a hematologist-oncologist based in Iceland who has been instrumental in advancing care and research of ME/CFS in Iceland and Europe. In 2022, he produced an educational film about...

The thing is, the effects of sunlight on skin appear to start with any exposure, even with just a few minutes of exposure, and there is a delayed reaction. Small fractions of the UVB dose that result in visible redness cause chemical changes. In that paper I linked above, there was a lot going...

I'm just going by what I and my son look like when in PEM, and the few photos I have seen of others in PEM. I'm sure about very little these days. But, fatigue due to car travel as a result of constant small muscle adjustments was what I was told about years ago. If fatigue and/or PEM is the...

People with PEM tend to have puffy faces, puffy eyelids. I am pretty sure that ibuprofen reduces my symptoms - and it reduces pain and reduces swelling. I understand that it works on prostaglandins. Women seem to be likely to produce more prostaglandins than men. Prostaglandins work on...

A minor point about how travelling in an ambulance might result in PEM (as mentioned in the first post): it is known that the vibrations of a vehicle cause tiredness. This article mentions a study where people sat in a car simulator with and without vibrations, and they became more tired with...

I've just caught up with the thread. That Long Covid Advocacy piece discussed back a bit is very impressive. e.g

We have split off a discussion to a new thread in the Possible Causes and Predisposing Factor discussion subforum: Pre-existing mental illness as a risk factor for ME/CFS

I think the heat maps with their clustering of participants are interesting. Fig 1: Long covid versus Healthy controls Look how the HLA genes (in that dense horizontal band in the middle) really differentiate the long covid people from the controls (LC people mostly on the right side of the...

There's a paywall unfortunately. This is a team from Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA The snippets suggest that these people understand a lot of the issues around ME/CFS and Long Covid. This isn't a trial though. I...

:confused: It looks rather like people who have a job and have to get up in the morning are less likely to 'have depression'. And people who are awake at night are more likely to 'have depression'. Of course, people with ME/CFS, and people with chronic pain are both more likely to be less...

Theory-organized: Model Introspection Self-organizing: General Population Model Performance That best model only had a sensitivity of 0.45 and specificity of 0.82. They noted that simple regression models performed no better than chance.

Could be useful to have a look to see what they measured with respect to fatigue. The authors seem quite positive about the capacity for measures to predict fatigue.

From Supplementary Data 1 - the exclusion criteria made it less likely for the ME/CFS participants to have a psychiatric history: So, I wouldn't use the Walitt et al study as evidence of psychiatric illness not being a risk factor for ME/CFS. But there certainly are others, including the...

Gosh, that was a roller coaster. Good, bad, ugly, confused... This Professor H. Prüß, what role does he have in the fatigue guideline he talks about, and how influential will it be?