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I wonder if that's the result of ME being uncomfortably caught between acute and chronic illness? With acute illness we generally expect that we have treatment of some sort and get well again. With chronic illness expectations from treatment are typically different. In some cases there may be...

A mixed bag, also apart from the uninformative abstract. The idea behind the study seems reasonable: people with FM and pwME struggle to exercise and suffer from pain. Based on studies on massage therapy in general MT may provide some of the benefits of exercise without actually exercising and...

That was my first thought, too. But I expect that somehow they'll manage to twist their findings into a version of there's nothing wrong with the peripheral nerves (normal pressure pain thresholds) therefore the high pain symptom load must be due to central sensitisation (amplification of normal...

A clear improvement on the previous version. :thumbup: One thing I find annoying is that this page - in common with seemingly every other ME/CFS webpage out there - links to other, general pages about sleep and pain management which recommend exercise. Something the ME/CFS page just told you to...

This. When well rested I have a sort of bi-phasic sleep, i.e. go to sleep ok, wake around 3am for a while, go back to sleep, wake around 5.30 am. Don't feel refreshed exactly but definitely somewhat better than the evening before. With PEM it's a very different story: I struggle to get to...

Question 1: what is GFAP? Question 2: what relevance would elevated GFAP autoantibodies have & could that really be a biomarker (if the finding stacks up)? Have only read the abstracts of the following. https://www.sciencedirect.com/science/article/abs/pii/S0955067415000137...

Heads up to anyone in the Tauranga region and fit enough to attend meetings. The Neurological Foundation is running a series of events, one of which is a talk by Dr Joanne Lin called "Uncovering the secrets of neuroinflammation", on 22 October. Dr Lin used to work in Jarred Younger's lab...

There seems to be a fashion for systematic imaging reviews. Here's a similar one (link below). Both conclude current studies are too few, too small and too varied to draw any firm conclusions. Only one of the reviews feels the need to repeatedly point towards the one study that claims to have...

I may be repeating some points already made. Started drafting this answer offline and then the power went off for a loooong 9 hours - and a lot of discussion seems to have happened in that time. I'm pleased you put that. It needs to be spelled out very clearly for those not familiar with PEM...

This. Because too few have been interested enough to even try to have a look. Plus different people use the terms differently, to ensure maximum confusion. These are some of the interpretations I've come across and can recall at the top of my head; there are likely to be others. No idea which...

This seems to be what they're proposing to develop: https://www.icf-research-branch.org/icf-based-documentation-form Currently there only seem to be ICF core sets for a limited number of conditions. I had a play with the electronic documentation form tool (see link in quote), using MS as an...

Impressive work @Michiel Tack :emoji_thumbsup: Decidedly unimpressive response from Cochrane :emoji_thumbsdown:

Lily Chu making sense, as usual.

A more nuanced review of placebo. Have only skimmed it, so my summary may be a bit off. The gist seems to be that under certain conditions, some placebos do create a physiological response. Mostly this requires pre-conditioning with an active intervention first, so if you've been using oxygen...

I think the key here is that it's not measuring fatigue itself, it's measuring the impact of fatigue. To my mind, what this MS Fatigue Impact scale highlights yet again is how differently we are being treated to people with diseases like MS. There isn't all that much wrong with any of the...

Can somebody explain figure 2B and the text relating to it? So the text says no significant difference in muscle fibre generated mitochondrial superoxide, neither with nor without addition of a nitric oxide synthetase inhibitor. Yet the graphs seem to show a difference. Figure 2B shows complete...

To be fair it is vastly better than it was, which was utterly appalling. Still not good, exactly - the exercise bit is way too garbled for that - but apart from that it now roughly aligns with IOM/NAM. Baby steps.

Ha ha. I often say that if only I could remember all the things I have 'learnt' listening to podcasts I'd be a very wise person by now. Alas...

Is there a way of testing metabolic profiles in those different microenvironments?

This thread has gone a bit quiet. Let's see if we can revive it. I'm currently binge-listening to the "Subtitle" podcast. Just a few of the topics, the range is wide and the concept of 'language' interpreted loosely: "Subtitle" is part of the Hub & Spoke stable of podcasts...