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  1. Snow Leopard

    Depressive symptoms at age 9–13 and chronic disabling fatigue at age 16: A longitudinal study -Aug 2019 Collin,Loades, Crawley et al

    Positive predictive values were poor, mean years - sensitivity - PPV (manually calculated by me for all you Bayes lovers) 9.7 - 11.5% - 6.3% 10.6 - 13.3% - 3.5% 11.7 - 9.84% - 5.0% 12.8 - 18.6% - 4.1% 13.2 - 16.7% - 6.8% 13.8 - 35.2% - 4.4% (curious loss of specificity, with a gain of...
  2. Snow Leopard

    Bristol CFS/ME clinic researching patients' problems with Chalder Fatigue Questionnaire

    More recently than May 2016, which is the only version on the Wayback Machine and did not have any references to such research. The notable part is they only care about difficulties answering the questions, not whether patients believe the questionnaire is relevant to their illness.
  3. Snow Leopard

    Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue, 2019, Milrad et al

    The problem is that there is a common bias, namely questionnaire answering behaviour. This method does not separate the effect of (a negative bias on) questionnaire answering behaviour from depression itself. The only way to resolve this is to use objective measures of fatigue on functioning.
  4. Snow Leopard

    Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, etc., 2019, Molero et al.

    The difficult part is establishing the relationship between cause and effect. Certain underlying risk factors may predispose for the outcomes above as well as doctors prescribing behaviour...
  5. Snow Leopard

    The hardware/software analogy of the BPS theory

    That is a bold claim... Sigh. It is not the lack of literal meaning that is the problem, it is the lack of meaningful application. There is no parallel to executing software on a body.
  6. Snow Leopard

    The hardware/software analogy of the BPS theory

    Brains are not arrays of digital logic gates with a fixed network configuration. Nerves themselves can die or regenerate, it is not merely the 'switching' (nerve firing) that is important. Epilepsy causes structural changes, so I'm not sure the analogy holds there. (note: a seizure is a...
  7. Snow Leopard

    ME Epidemiology - prevalence and peak ages of onset

    Unless they provide a histogram, and account for participation biases... There may still be a lack of sample size to make any conclusions about an earlier age peak too.
  8. Snow Leopard

    ME/CFS Epidemiology - sex ratios, female predominance

    Copied post Unless they provide a histogram, and account for participation biases... There may still be a lack of sample size to make any conclusions about an earlier age peak too.
  9. Snow Leopard

    Psychiatric conference in Norway nov. 2019 themed "Stressology" (Wyller among lecturers)

    I can't help but chuckle at the word "stressology". The problem with stress is the more people who use the word in ever increasing range of contexts, the less specific the meaning seems to be and the less useful the word is as a result. Despite the fact that he has tried to test this...
  10. Snow Leopard

    ME Epidemiology - prevalence and peak ages of onset

    I need to clarify that the age doesn't really tell us much. The average age at enrolment in the study was 44.9, and the study only went for 2.4 years so this study can't really capture what happens at other ages.
  11. Snow Leopard

    Predictors of New Onsets of Irritable Bowel Syndrome, Chronic Fatigue Syndrome and Fibromyalgia: The Lifelines Study, 2019, Monden et al

    I made a mistake, the lifetime prevalence didn't report sex, 57% was the overall sample. However 56% of the new cases were women.
  12. Snow Leopard

    The hardware/software analogy of the BPS theory

    Because people sat down and wrote "software", which ultimately a list of binary logic instructions telling a digital computer what to do in a linear manner. Formal languages (including programming languages) are very different from our thoughts, or biological signalling networks. Life is a...
  13. Snow Leopard

    Protocol: Persistent physical symptoms reduction intervention: a system change and evaluation (PRINCE), 2015 onwards, Chalder, Moss-Morris, et al

    www dot curablehealth.com/podcast/fiona-recovery-story-chronic-fatigue-syndrome I haven't listened to the interview and there is no transcript, so I have only read what was written. From a first glance, it is notable that there is no discussion of whether she is in remission and what she has...
  14. Snow Leopard

    The hardware/software analogy of the BPS theory

    Moderator note: A series of posts has been split from the thread 'Protocol - Persistent symptoms Reduction Intervention - A system change and evaluation PRINCE, 2015 onwards, Chalder Moss-Morris et al' ****** The software/hardware analogy is indeed nonsense and it invokes the same mind-body...
  15. Snow Leopard

    A perspective on causation of the chronic fatigue syndrome by considering its nosology, 2019, White

    The impact on the satisfaction of human needs in ME & CFS is often worse than the comparison illnesses, hence a deeper examination is needed before forming any conclusions about the degree of causation and 'expected' impact.
  16. Snow Leopard

    ME Epidemiology - prevalence and peak ages of onset

    Another 2.4 year prospective study. (mean baseline age of entire population was 44.9, 57% women) https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3427300 New onset 0.08%/year, mean age of 48.0. 56% of new cases were women. "Lifetime diagnosis at baseline" was 1.3%. (note this was...
  17. Snow Leopard

    ME/CFS Epidemiology - sex ratios, female predominance

    Copied post Another 2.4 year prospective study. (mean baseline age of entire population was 44.9, 57% women) https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3427300 New onset 0.08%/year, mean age of 48.0. 56% of new cases were women. "Lifetime diagnosis at baseline" was 1.3%. (note this...
  18. Snow Leopard

    Predictors of New Onsets of Irritable Bowel Syndrome, Chronic Fatigue Syndrome and Fibromyalgia: The Lifelines Study, 2019, Monden et al

    The study is somewhat superficial in it's exploration of prognostic variables and it is possible the prognostic variables shared between IBS and FM may reflect diagnostic biases. The authors also state "We had no measure of sexual abuse which has been mentioned in previous reports as a...
  19. Snow Leopard

    A perspective on causation of the chronic fatigue syndrome by considering its nosology, 2019, White

    I just skimmed the transcript as well, neither MS or PH stated anything along those lines on the radio show.
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