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Abstract Reducing estrogen in women results in decreases in energy expenditure, but the mechanism(s) remain largely unknown. We postulate that the loss of estrogens in women is associated with increased accumulation of bone marrow–derived adipocytes in white adipose tissue, decreased activity of...

I'll be receiving the Health Canada authorized adapted version Moderna Spikevax COVID-19 vaccine that targets the Omicron BA.4/BA.5 subvariants in a couple of weeks. I declined the flu vax b/c they only administer it at the same time for home visits. I would have preferred the jabs on...

Endothelial dysfunction has been proposed to play a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its post-acute sequelae. Flow-mediated dilation (FMD) is recognized as an accurate clinical method to assess endothelial function. Thus, we performed a meta-analysis of the...

The funny thing is that my GP didn't feel I needed to supplement with B12 when it was borderline low, but a couple of years later after taking B12 tablets and retested, she had the receptionist call to tell me to immediately stop taking it b/c it was 'high!".

I didn't have symptoms of B12 deficiency, but when I was tested years ago I was borderline low. I took B12 shots and methB12 tablets but didn't feel any difference. So who knows.

The paper also includes iron deficiencies.

@Arnie Pye Have you see the thread I posted here

Good thread :laugh:

Abstract Epstein-Barr virus (EBV) persists in human B-cells by maintaining its chromatinized episomes within the nucleus. We have previously shown that cellular factor Poly [ADP-ribose] polymerase 1 (PARP1) binds the EBV genome, stabilizes CTCF binding at specific loci, and that PARP1 enzymatic...

https://www.healio.com/news/rheumatology/20221110/long-covid-and-me-a-true-story Although I am better in many ways, I am not back to normal yet consider myself extremely fortunate in comparison to the many patients I see with neurocognitive complaints, from conditions ranging from fibromyalgia...

I'm seeing the term 'immunity debt' circulating on social media these last couple of weeks spreading misinformation. Immunity debt hypothesis suggests that people's immune systems are weaker now due to lack of exposure to viruses from wearing masks, staying home and vaccines, so now our...

Why are our government officials 'studying' whether we need to reinstate mask mandates with the increase of RVS, Covid and Flu overwhelming our ER's?:confused:

A new study points to a pathogenic role for compromised anti-SARS-CoV-2 responses in the cerebrospinal fluid, likely resulting in incomplete virus clearance from the brain and persistent neuroinflammation, in the development of neurological. Abstract Coronavirus disease 2019 (COVID-19), which...

Perhaps this will show why some of us feel much better in the evenings?

Abstract Background The post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), also known as post-acute coronavirus disease 19 (COVID-19) or the long COVID syndrome (long COVID) is an emerging public health concern. A substantial proportion of...

Background: Fatigue and cognitive complaints are the most frequent persistent symptoms in patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to assess fatigue and neuropsychological performance and investigate changes in the thickness and...

Abstract Background Discerning the mechanisms driving orthostatic symptoms in human beings remains challenging. Therefore, we developed a novel approach combining cardiac and cerebral real‐time magnetic resonance imaging, beat‐to‐beat physiological monitoring, and orthostatic stress testing...

Background: The systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (e.g., deep vein thrombosis) and the inflammatory response...

New research uncovers the role of mast cells in Covid-19, and mast cell stabilizers could be efficient and safe in tackling the blockage of blood vessels. https://www.birmingham.ac.uk/news/2022/targeting-mast-cells-could-be-beneficial-to-treat-covid-19-patients