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  1. Sean

    In vitro B cell experiments explore the role of CD24, CD38 and energy metabolism in ME/CFS, 2023, Armstrong et al

    I have long been of the view that most of what we see and know so far about ME is the patient's physiological and behavioural reaction to the underlying problem, the attempts to deal with a pathological demand on otherwise normal healthy systems now being forced to operate beyond their...
  2. Sean

    Trial Report The impact of bed rest on human skeletal muscle metabolism, 2024, Wüst

    So it isn't deconditioning. Who knew? Identify and interrogate the assumptions is the first step in assessing any hypothesis. The deconditioning assumption is critical to the psychosomatic hypothesis of ME. Its proponents have never interrogated that assumption. How much time and resources...
  3. Sean

    Trial Report Videoconference-delivered group cognitive behavioral stress management for ME/CFS patients who present with severe PEM: a RCT, 2023, May

    Cognitive restructuring (i.e. modifying unhelpful thoughts) Who decides what is an 'unhelpful thought'? The sheer hubris required to be able make to claim about one's ability, given the overwhelming track record of its failure (and not just for ME), is unbelievable. About as low a bar as it gets.
  4. Sean

    Earseeds, Acuseeds

    Piss off, 'doctor'. You have dined out on our suffering for far too long. Go find an honest job. Some things should be cancelled, like this garbage.
  5. Sean

    Earseeds, Acuseeds

    https://www.thecanary.co/opinion/2024/01/24/acu-seeds-dragons-den-2/
  6. Sean

    All-Cause and Cause-Specific Mortality Among Individuals With Hypochondriasis, 2023, Mataix-Cols et al.

    In the case of something like illness anxiety, where it’s pretty clear that there’s not an underlying serious disease, Spot the age-old problem with that logic. Of course the whole thing depends on how robust is the diagnosis of hypochondriasis. Which it isn't. Not even close.
  7. Sean

    Earseeds, Acuseeds

    Yes, yes, yes. All very interesting. But can she realign my Chakras with the Eternal Cosmic Oneness? It takes a properly qualified charlatan to do that.
  8. Sean

    CAR-T therapy

    It is, in principle at least, amenable to more objective measures. How practical that might be is a different story.
  9. Sean

    Review nature reviews cardiology: Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health care burden, Fedorowski et al, 2024

    They love claiming they are both the victims and the heroes of the story, when they are neither.
  10. Sean

    Advice on mask-wearing to protect against Covid-19

    Yes, important to keep in mind that is the minimum standard they have to meet – removing at least 95% of the target range of particles. They will typically do a lot better than that.
  11. Sean

    Brain FADE syndrome: the final common pathway of chronic inflammation in neurological disease, 2024, Khalid A. Hanafy

    1. The dominant paradigm has, until recently, been the psychosomatic one. 2. In no small part due to 1, the post-infectious hypothesis has still not been adequately researched. 3. The emergence of Long-Covid seems to me a pretty good piece of evidence that this is post-infectious. Not...
  12. Sean

    Advice on mask-wearing to protect against Covid-19

    I view masking up probabilistically. The right kind of mask, used properly, greatly decreases the risk of inhaling virus, and the quantity of virus inhaled if you are exposed. Particularly effective if your risk is casual, like mine. Meaning I am not in contact with the public much, so masking...
  13. Sean

    A biopsychosocial approach to persistent post-COVID-19 fatigue and cognitive complaints: ... 2024 Klinkhammer et al

    The game here is to flood the literature with apparently independent studies, all 'reproducing' the same basic result, using the same suite of flawed assumptions and methodology (mainly inadequate control of open label self-report measures, but also cherry picking evidence, selective...
  14. Sean

    1/18/2024 US Senate hearing on Long Covid of the HELP (Health, Labor, Education & Pensions) committee

    Also worth noting that, as I understand US politics, health research has long been one of the most bipartisan issues in Congress. If there is one thing the two main parties are more likely to agree than not it is this one.
  15. Sean

    Earseeds, Acuseeds

    She was once told by doctors that she would never work again or have children. Want some hard evidence for that. If anything in the UK she was most likely told that she just needed some CBT and GET, and that recovery was possible, with the right attitude, of course.
  16. Sean

    A Review of BMJ Best Practice Document on Chronic Fatigue Syndrome by Professor James Baraniuk

    Although previous randomised controlled trials (RCTs) have reported benefits to structured GET in the management of ME/CFS,... If anything, the body of studies on GET from the psycho-behavioural club are characterised by their persistent lack of adequate control. They have also not reported...
  17. Sean

    Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis, 2024, Maas genannt Bermpohl et al.

    Methods Randomized controlled trials... Stopped there. Anybody who can describe the body of psycho-behavioural studies for CFS as controlled really hasn't grasped the concept of control.
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