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A bit more detail about Aptinyx https://ir.aptinyx.com/news-releases/news-release-details/aptinyx-reports-positive-top-line-data-phase-2-study-nyx-2925

I like how she wrote of how the pain is different in MS and in Fibro.

Yeah, I've got my eye on this drug development for fibro. But who knows. Phase II is just a small human sample trying to get the dosage right. The company is seeking money (I think) for the huge cost of a multi-center Phase III trial. Fingers crossed.

anger ruminations in fibromyalgia https://onlinelibrary.wiley.com/doi/abs/10.1002/pmh.1445 My personal experience with fibro is that the pain is quite extreme and makes me irritable in many ways. When the pain is sometimes relieved by an opioid, I am my normal self--not "angry." Again, this...

I ain't no scientist, but I know from experience that the brain runs on glucose. And the brain's in charge of everything, so I need a certain carb level to feel okay (or whatever passes for that these days.) Diabetic diet (carbs limited) is good. Still, hard to not OD on carbs: popcorn, chips...

Here's some info about the 2016 changes: https://acrabstracts.org/abstract/2016-revisions-to-the-20102011-fibromyalgia-diagnostic-criteria/ And ....https://people.clarkson.edu/~lrussek/2016FMS.pdf This seems to be a/the screening tool for the 2016 criteria, or a version of it.

I hate spending two hours trying to decipher why bogus science is bogus.

Parsing it down: Pappollo proposes that insulin resistance causes fibromyalgia. That metformin is highly effective in reducing fibromyalgia pain. He also applied for a provisional patent for a novel treatment program for fibromyalgia and myofascial disorders (could be based on metformin?). I...

My critique of this study: Nowhere does it mention how long each participant has had fibro. The longer one has it, the less likely one is to be physically fit one the more likely one is to be overweight (higher BMI). This is a major risk factor in developing prediabetes (IR, elevated HgA1c)...

I'm reading about it now and it's like CBT crossed with mindfulness. Kind of a rehash. Really can't see how it can be therapeutic for ME/CFS. Ka-ching for the psychs.

Couple of points of reference about the concept of psychological flexibility. However, I fear it's widespread use and waste of research dollars. also https://www.sciencedirect.com/science/article/pii/S0272735810000413?via=ihub And here is another tack...

I came across this https://www.apa.org/pubs/journals/releases/amp-a0035623.pdf It's about CBT and Acceptance and Commitment Therapy (ACT) in treating chronic pain, and the history of research both negative and positive. And the result is not convincing, to say the least. This is for chronic...

CBT was originally developed by David Burns to treat self-defeating thoughts in depression. Interesting and probably useful. Then in 2005 or so, CBT was being used in chronic back pain. Since then, it's become a first-line therapy in many difficult conditions. Trouble is that this generalizing...

Interesting about: increased level of oxygen (but by how much, it's not a hyperbariac oxygen chamber--that, is another Israeli research study on pain), and the sun, and mineral (and fungi, by the way) levels in the sea. But, in essence, my take-away is that the research is promoting this...

Long way to go for spa therapy. Plus having to endure the invasive customs search making sure you and your friends don't have anti-Israeli politics. Here's a link to the spa and Dr. Harari (under "research").https://www.lothotel.com/clinic/ The Dead Sea receives a huge dose of solar radiation...

Thanks, @Trish, that's exactly what I needed to hear. Thinking I need to change my life according to my worst day/week/month ever may be catastrophizing or it may well be true enough. In any case, I'm out of my usual state of denial of illness for once. At least I am getting better at...

Whoops here. I'm having another catastrophizing session (i.e. bad week). OK, I'm exaggerating = I'm catastrophizing. It's just that Saturday, I had a two-hour conversation with some very bright and empathetic neighbors after a short walk. Shouldn't have. My personal time limit on any outing is...

CDC website has good info on the risks of feces, mainly when cleaning the cat box, new kitten, etc. https://www.cdc.gov/parasites/toxoplasmosis/gen_info/faqs.html