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The authors are from Spain and the US. There's a weird bit about opioid use: There was no matching of subjects by gender and BMI: LC: 18 males; 32 females....... mean BMI 29.5 Fibromyalgia: 50 females ........ mean BMI 31.6 Controls: 4 males, 2 females .......... mean BMI 25 And, only 6...

BACME appears to be a 'professional organisation', as in, an organisation set up to support a certain group of people who earn their living in a particular way, like an association of engineers, or occupational therapists. Do professional organisations normally qualify for grants from that NL...

Thanks @SNT Gatchaman. The thymus is surely a neglected organ - it gets none of the glory that the heart, or even the kidney, gets. A lot of the second hour of the video is about titanium dioxide. Titanium dioxide can be in a wide range products, from toothpaste to dairy products. There...

At the one hour mark there are some comments on gut permeability and about the 'Celltrend' adrenergic autoantibodies. "All these ME/CFS and POTS people had these adrenergic autoantibodies.." Actually Cyber, before a theory is built on the presence of the autoantibodies, I think we have to...

Mold at 50 minutes. A list of specific symptoms that are supposed to be associated with mold is given. Then VOCs - also specific symptoms given (stimulated feeling). No evidence given for these associated symptoms at this point. Third category that Cyber believes is a major driver of CFS...

30 minutes in, there's a discussion of factors that might damage the epithelial barrier. This is also discussed in Cybergreen91's post above. Chemical exposure, viral infections, connective tissue disorders (that affect the tight junctions between the epithelial cells). If the epithelial...

27 minutes in, there's a discussion about the Hornig 2015 paper which reported high levels of inflammatory cytokines in people who had had CFS for less than three years and low levels in people who had had the illness longer. It's a nice story, but it has not really been replicated. I think we...

Welcome to the forum @Cybergreen91. For sure, environmental factors may be part of the cause, at least for some people. We only have to look at Gulf War Illness, which is at the very least 'quite similar' to ME/CFS, and the strong indications of environmental causes for that syndrome, to see...

Yes, defining PEM has been difficult, and is core to finding out what causes it. To give an example, I participated in a 2xCPET. On the night after the first CPET (and plane travel), I had a bout of what I call PEM. This was feeling very unwell, deeply exhausted, with my whole body feeling as...

Isn't that an odd definition? Surely 'the induction or worsening of symptoms induced by ...an active therapy' is the production of side effects. Some of those side effects may well be entirely real and explicable. I think this idea that nocebo effects are more common in women is probably...

Here are links to the research priorities, in 8 groups: Here's an example - the Nervous System Priorities: There's a seven minute video that tells you how to provide feedback. https://ninds.ideascalegov.com/a/pages/mecfsguide

We now have a thread for discussion about this NIH request for feedback on ME/CFS research priorities: 2024: USA NIH NINDS ME/CFS Research Roadmap - input on research priorities sought by 8 March 2024

Declining trust in Zeus is a technology The latest blog from Adam Mastroianni: There are some stats suggesting there is declining trust in educational institutions, then It reminded me of listening to a doctor on the radio recently who was very concerned that people are spending a lot of...

:thumbup: all power to you @Solstice On peripheral O2 extraction So, an interesting difference in peripheral oxygen extraction (lower in Long Covid). But the sample size is even smaller than the whole (fairly small) study sample size. So, I think, essentially oxygenation was reported...

I don't think it's quite like that though. The task is in fact being achieved and there is a willingness to do it again, it's just that incredibly rapid reduction in the ability of it to be achieved again. I get that too, I'm not sure if I'd say it's necessarily a part of PEM, it depends on...

So the quantification of GABA+ is from one relatively small bit of brain. Just noting this. Abnormal results might be the result of some technical problem or some medical problem unique to the subjects, but might also be related to a transient impact of PASC. (It would be good to see this...

Sample size of 18, with their symptoms having reportedly relatively mild impacts. 20 controls

I think I'm not talking about the absolute loss of function in a stroke (that arising from the "hole" in the brain), some of which can be ameliorated by finding different ways of doing things. Instead I'm talking about how some tasks can be achieved, but not repeatedly. What is the process of...

Someone close to me has recently suffered from a stroke that has affected their language ability. This person now has to work hard to read simple words, one at a time. And he can only do that for a while before feeling exhausted. When rested, he can write a few sentences for a thank you note...