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Ingebjørg Midsem Dahl did, and her book is called "Classic pacing" in english. Haven't read it myself but seen it recommended on some norwegian forums :) http://www.pacinginfo.eu/ I don't feel like reading this other >60 pages long thing if I'm honest. From what you've all written it seems like...

Agreed. But even if the diets might look different, include different things, they still generally have something in common. Like nutrient density. I must admit I am one of those that think diet can make a huge difference in someones life. And I don't think people who talk about a diet "curing"...

No worries, there is actual research that dark chocolate is good for creating a happy microbiome environment. >80% cacao and it's all good. At least I don't feel the dark chocolate I eat in any way diminishes the general high nutrient diet I have ;) I believe diet should be used as part of...

It is as you say, the B12 is there but the cells can't use it. When this happens, the levels of methylmalonic acid rises, as it is metabolized in a process dependent on B12.

I would love such a study too! There are as you say so many factors, and that some of these can be different between patients and controls should be no surprise to anyone. I will be analysing metabolome data from a controlled diet study the next few months, hopefully I will learn more about...

Definitively, and it might also have to be more than just one day of specific meals.

You can test for functional b12 deficiency by looking at methylmalonic acid levels in the blood.

Being close and personal (physically) with someone could cause exchanges of bacteria (I think this is also observed between animals and their owners). And I'm not taking about being unhygienic, like @rvalee says, we have many microbiomes and some are more accesible than others (for lack of a...

I'd rather see a study on cancer in the gastrointestinal tract, where it is possible to get high enough concentrations of some of the anti-cancer or anti-inflammatory or other beneficial compound from the veggies*. It can't necessarily be absorbed and get to the cancer cells in the amount that's...

What Hutan said. I haven't got to read the study except glanced at the participants and I'm skeptical. But I like metabolomics so I look forward to read this in more detail when I can spare the energy.

The problem with zonulin is that it can be expressed in other tissues than the gut, so when taking a bloodtest you can't say where it originates from and where it interacts with tight junctions to loosen them up. Regarding wheat, gliadin (the most common problematic protein in gluten) can cause...

I don't think of it as "Off limits", just hard. During the years I've been at university, ME has not been mentioned in lectures. I take subjects related to cell biology, biochemistry, metabolism, nutrition and general health. Cancer has been a "model illness" in many of my classes, metabolic...

This. Too tired to write a lot, but as someone thinking about gjetting a phd, I am also dependent on being able to make a living for myself when I am done. As interesting as ME is to me from my cell biology background, I don't see how I would be able to support myself following that direction as...

Not everyone who has an illness where diet is a clear culprit for making them ill/worse are able to just change their diet and recover. It is hard. And even if diet is not a cure (I don't believe it is for ME), it is still important when ill to eat a nutrient-dense diet. I would say sick people...

One of my textbooks has "post exertional fatigue" as a symptom of CFS. Patients will have an increase in fatigue lasting one or two days. Oh if only.

JAKs are involved in lots of things though. I'd hope we could find a more specific treatment than that.. A girl can dream.

Some proteins need the disulfide bridges created in an oxidative environment, though. So saying that correct folding of proteins (like in "all proteins") requires reduced glutathione feels like a stretch to me, although it's not my area. Reading about "mitochondrial Precursor Over-accumulation...

Sorry I've just been through exam season and my mental fatigue is adding up. When you are talking about folding and reducing environments, do you mean how it affects disulfide bridges in the protein? A lack of reduced glutathione > oxidized cysteines and formation of disulfide bonds? I'm not...

I'm not sure level of activity changes how a protein will be affected by free radicals. Fatty acids (unsaturated ones are most prone to this) are not enzymatically active for example, but can still be oxidized, because of their chemical properties. Mitochondrial membranes could be affected...

But oxidative stress would surely affect other proteins as well as the mitochondrial ones? It does not discriminate.