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This poll is an updated version of the one from 2018 Biphasic sleep is a subset of problematic sleep maintenance. Some people many wake for half an hour and fall right back to sleep. Others may stay awake for several hours before going back to sleep--this is more like bi-phasic sleep.

https://www.nytimes.com/2020/09/02/health/als-icebucket-treatment.html?surface=home-discovery-vi-prg&fellback=false&req_id=641572005&algo=identity&imp_id=185390044&action=click&module=Science%20%20Technology&pgtype=Homepage MECFS needs its own ice bucket challenge....

Specifically, what types of kinase inhibitors do you think might benefit ME/CFS patients (to interrupt signaling)?

https://pubmed.ncbi.nlm.nih.gov/31104106/ In vitro effects of antipsychotics on mitochondrial respiration Maybe this fries your mitos like anti-virals...

I have an advisory role on the Columbia U ME/CFS center. They wanted to know if folks had any questions for their researchers on their study "Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS, 2020, Lipkin et al" If you have any...

partially about “long Covid” aka ME/CFS

https://www.nytimes.com/2020/08/28/opinion/coronavirus-misinformation-faceboook.html?action=click&module=Opinion&pgtype=Homepage One of the authors Spencer contracted Ebola.

I've reached out via a Columbia U. liaison to Lipkin, Horning and Komaroff. Do I get a Cadbury Flake or the Fruit Pastilles? To reach Ron Davis and Ron Tompkins try contacting Chris Armstrong carmstrong@omf.ngo Somebody else do this. You get an old standby--Hershey bar with almonds.

Here is part of the abstract from the Rekeland (Fluge) cyclo study https://www.s4me.info/threads/intravenous-cyclophosphamide-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-an-open-label-phase-ii-study-2020-rekeland-mella-fluge-et-al.14925/ Results: The overall response rate by...

Moderator note: This post and following posts have been moved from this thread: A request to those involved in ME research to indicate their position on spinal surgery I could follow up on these two and maybe Komaroff. But I think it needs to be addressed as to how several people got...

Whatever happened to this? Did Perez respond to the Tuller letter? @dave30th I sort of liked Perez’ admission that that he didn’t really care about what the data showed—very frank of him!

List of drugs for MS https://www.nationalmssociety.org/Treating-MS/Medications

Another drug for MS, still nothing for MECFS. https://www.medpagetoday.com/neurology/multiplesclerosis/88195

Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/

Looks like it’s still under consideration for the EU. EMA Panel Backs Filgotinib (Jyseleca) for Rheumatoid Arthritis https://www.medscape.com/viewarticle/934782

Is this sentence as bad as I think it is? Hmmm maybe it is indistinguishable because IT IS MECFS. (from Komaroff article)

https://www.barrons.com/amp/articles/fda-rejects-potential-gilead-blockbusters-scrambling-drug-stocks-51597846377

https://www.fiercebiotech.com/biotech/fda-rejects-gilead-s-would-be-blockbuster-filgotinib-over-toxicity-concerns Testicular toxicity! Wow—This is the drug KDM was promoting, and planning to do trials with. See here...

https://en.wikipedia.org/wiki/Upadacitinib https://www.rinvoq.com/ Janus kinase inhibitor that is selective for the JAK1 subtype of this enzyme--for the treatment of RA @Jonathan Edwards Any chance that this might also work for ME/CFS? I ask because I am bombarded with TV commercials for...