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Yea, all these more challenging cognitive tasks will have massive interindividual variability. The best you can do is find one that reasonably discriminates patients from the best possible matched controls, and then, as you say, you use it to measure change within individuals.

This is not a great task. You want something that involves more complexity imo. Anything that just measures slowed responding is too general, won't be a specific enough marker of CFS-related cognitive dysfunction. This is quite a good example of a continuous selective attention task.

Good question. Objective to me means something that does not involve people having to judge for themselves how they think their function is. So any measure that doesn't involve self-evaluation is a great start. Step 1 is to pick a task which taxes people cognitively in the right kind of way. I...

From the abstract: Its like saying "Little is known about exactly how long fairies' legs are". Both questions seem to rest on a huge elephant of an assumption.

Yea, CBT is good for whatever ails you. That's the joy of non-blinded studies relying on patient self-report. Homeopathy has proven benefits too, if you study it the same way (you don't blind patients to what medicine they got and you ask them to report how they feel).

I think my browser's crap at ordering sequenced tweets. Its still displaying them the same way for me whatever I do. Need someone with a decent browser to do some screenshots! Edit: thanks @Esther and @Alvin! I feel like an idiot now because everyone probably read that thread except me.

On the topic of harrassment, I read today that UCL's The London Conference on Intelligence had to be run in secret, because of potential harrassment from militant anti-eugenics activists.

"Its not what it looks like, doctor. I was administering a coffee enema"

I missed it, and in case anyone else did, here it is, the whole sequence:

I suggest we do not discuss the issue of harrassment any more here. By doing so, we are allowing it to sidetrack the more important issue - the damaging research and political agenda being described in this talk. And its potential harms to children and families. By continuing to discuss the...

Yea, I'm starting to get angry now too. The work this woman does harms children and ruins families. Its dangerous and misguided. Everything else pales into trivialities compared to that. If you want to have a discussion about the best strategies for advocacy, @petrichor, then we have that. I...

If you're enjoying a little light fun at Gwyneth's expense, this article is hilariously tongue-in-cheek: https://www.theguardian.com/lifeandstyle/lostinshowbiz/2017/nov/30/have-a-happy-homeopathic-christmas-with-gwyneth-paltrow

PS You can support them on kickstarter Edit: Oh, it seems that round has closed.

You make some excellent points, @petrichor, that have stimulated worthwhile discussion. It probably feels like people are attacking you because they disagree strongly with some of the points - but at the same time, they respect the way you've expressed your views enough to want to present the...

About coffee enemas being sold by Gwynneth's company Goop. https://www.theguardian.com/commentisfree/2018/jan/09/gwyneth-paltrow-goop-coffee-enema-colonic-irrigation Its worth the read just to get to the comments. Some gems: (some ruder ones there too that were very funny :whistle:)

Thanks, @Jonathan Edwards!

@Jonathan Edwards, they describe helper T cells as having a role in antibody driven immunity (detecting antigens, I think it said). Is this their primary role, or do different helper T cells do different things?

You make good points, @petrichor. There IS something different about Dr. Crawley - when you compare her with some of the staunch BPS advocates. The latter are ideologically driven, Dr. Crawley isn't. She's just sort of riding on the seat of her pants. Her approach is more simplistic and...

I think we agree here, @Jonathan Edwards. I certainly don't think that limitation applies to you!