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    Diagnose Lyme disease if bull’s eye rash is present, says NICE

    That was, if I'm not mistaken, the standard practice in the US by 1999, ie, a bull's eye was diagnostic. Oh, they qualified it with dimensions and the like because of STARI eventually, but regardless. Evidently 1999 may have been a banner year in Lyme mishaps. That year I had over 100 deer...
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    'Consumer-Contested Evidence: Why the ME/CFS Exercise Dispute Matters So Much' PLOS Blog post by Hilda Bastian

    There are ME/CFS patients who have been sick for many years, sometimes decades. Some clinicians (Bell?) have suggested that a portion of these long-term patients have become over the years so used to their condition, so inured to the symptom cluster, that they actually imagine themselves as...
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    Daily Telegraph: Living hell or yuppie flu? The confusing fog of chronic fatigue syndrome

    I doubt this would hold up to proper scrutiny. I am reminded of at least one study that demonstrated prayer improved survival rates in cancer patients.
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    Post-bacterial infection chronic fatigue syndrome is not a latent infection. Melenotte et al. (2019).

    "Psychological trauma may be part of these subjective symptoms." Bets? ETA: I find this abstract troubling. Planting the psych seed is disturbing in its own right, but reducing PTLDS to an assumptive close with only subjective symptoms borders on absurd. I have been treated for Lyme, and I...
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    Her Face Droops Without Explanation. Can You Tell Us Why?

    It says she has a history of Lyme. That means a tick bite. I'd check for all TBDs that may be possible where she lives or traveled to that can progress to neurological symptoms. That list would include bacteria and viruses and parasites. I am unclear what tests they even ran to determine she no...
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    Rules for interpreting the significance of IgM and IgG antibody titers

    I get some values, e.g. EBV IgG numbers. But for Coxsackie viruses its more whether or not my ratio is high, although I am provided that ratio. Lyme advocates saw the algorithm for diagnosing Bb evolve and embraced in real time; it was not difficult to uncover its flaws. Of course...
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    Rules for interpreting the significance of IgM and IgG antibody titers

    Yes. I must confess that sometimes I am taken aback at how provincial GPs and infectious disease doctors can be. And how arrogant and demeaning in their casual ignorance.
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    Rules for interpreting the significance of IgM and IgG antibody titers

    @Hip, you may want to check out a reputable Lyme site. They pretty much all have references for explaining IgM/IgG. You could try LymeNet Europe - it doesn't have much traffic these days, but it is study and reference rich. Your table seems fair enough. One observation is that interpreting a...
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    Real-world studies no substitute for RCTs in establishing efficacy (2019)- Gerstein McMurray Holman

    Yes. Not only are they not perfect, but their results can be "crafted", as perhaps evidenced by the three notorious Lyme RCTs. Maybe that potential is more reflective of GIGO.
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    One-sided weakness

    Facial palsy? Evidently some channelopathies can impact a limb, or half a body or a specific area of the body - it does not need to be global, although it certainly is for some. I do not know why it works that way, but it seems it can. My wife's episodes can be isolated that way. Lots of what...
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    One-sided weakness

    So, channelopathies can be weird like that, and they can manifest as profound weakness in certain parts of the body (while other parts of the body remain seemingly ok). I am certainly not trying to diagnose, but if there were a good battery of channelopathy tests, I might be inclined to look...
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    Internet-based self-diagnosis of Lyme disease caused death in a young woman with systemic lupus erythematosus. (2019) Strizova et al.

    This abstract strikes me as a little odd for a couple of reasons. I will try to explain why. True. It's the classic 80/20 split, though, or at least that is historically pretty much the accepted thought. So, yes, a majority are cured, but 20% are not. With over 300,000 Lyme cases annually in...
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    Internet-based self-diagnosis of Lyme disease caused death in a young woman with systemic lupus erythematosus. (2019) Strizova et al.

    This has not been my experience. In fact, after dwelling in Lyme Land for almost 20 years, I doubt it is the experience of most who contract a tick-borne disease. The typical Late Stage Lyme patient, as far as I can see, tests positive on multiple bands, even multiple tests (and for multiple...
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    Finally, I’ve found what caused my brain fog, chronic fatigue, depression and aching joints...an insect bite! - James Delingpole

    This article doesn't feel right to me. Borrelia Miyamotoi? That's not a clinical diagnosis, as far as I am aware - you either test positive or you don't, and there are not many labs even testing for it. There are less than 30 Lyme-ish species. Miyamotoi - theoretically - is relapsing fever; keep...
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    Evidence of widespread metabolite abnormalities in ME/CFS: assessment with whole-brain magnetic resonance spectroscopy (2019) Younger et al.

    I would have measured cognitive functioning. Associating mood disorders with ME/CFS - IF that is something he was approaching - is potentially playing into the wrong hands needlessly. Work with word choice or reasoning or abstract thought or basic math deficits. Why venture into such an area...
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    Evidence of widespread metabolite abnormalities in ME/CFS: assessment with whole-brain magnetic resonance spectroscopy (2019) Younger et al.

    Perhaps. I'm not sure this approach does not incorporate the same pitfalls with which we are now so familiar with decades of research that excluded women for diseases that impacted both genders, much to the detriment of women. Moreover, there may be an argument that says any cohort should...
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    Evidence of widespread metabolite abnormalities in ME/CFS: assessment with whole-brain magnetic resonance spectroscopy (2019) Younger et al.

    Without having read the paper, two items posted here jumped out: Why were only women tested, and what's with "fatigue and mood symptom questionnaires"? Mood symptoms?? Whatever he may be glimpsing with MRS metrics, what footprints does he imagine he is seeing, as they may not be ME/CFS.
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    Measuring fatigue. Discussion of alternatives to questionnaires.

    A problem would be when anyone in the medical community takes that questionnaire data, and misinterprets it as either delusional or as reflective of everyday symptoms that are exaggerated or inappropriately attributed by the patient as being unusual. So it wouldn't necessarily be the...
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    Measuring fatigue. Discussion of alternatives to questionnaires.

    In the absence of legislation that gives patients legal recourse when any doctor dismisses or minimizes a patient's reported symptoms, patients will come out wanting. Placebo effect comes to mind, and that, of course, is the tip of the iceberg.
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