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    Severe posterior hypometabolism but normal perfusion in a patient with CFS/ME revealed by PET/MRI, 2018, Sahbai et al.

    So this could be helpful for a number of teenage girls who developed "CFS" following Gardisil injections ?
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    Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

    Step 1 - define area of interest Step 2 - conduct a literature review to enable you to either build on previous findings/ explore a " gap" in knowledge From undergraduate stats lectures- first lecture. I take it the literature review was as all encompassing as the above result would suggest...
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    Physical Activity and Sleep in CFS and Fibromyalgia Syndrome: Associations with Symptom Severity in the General Population Cohort, 2018, Joustra et al

    Are actometers worn all the time? From a previous thread relative to paediatric EC studies i seem to remember that their use was intermittent ( could be wrong) . In which case what is being measured is a key question. The link to activity and misdiagnosis is interesting and may be another...
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    A predictive algorithm to identify genes that discriminate individuals with fibromyalgia syndrome diagnosis from healthy controls, 2018, Saliqan et al

    I agree, but virtually impossible to get anyone to consider this. I' ve given up with my GP and no private providers do any other investigative processes anywhere near us. I am hoping that this gets further study.
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    Cochrane Exercise Review Withdrawn - Individual Patient Data

    A couple of queries Is this the proposed study whose reviewers savaged it and was likely never to be published? Is this a means of not providing data that can be analysed by others ?
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    Livestream Alan Light, PhD today at 6pm MST "New findings suggest that multiple mitochondrial mutations create susceptibility for ME/CFS"

    Similar to @BeautifulDay ' s theory that some genetic mutations create a predisposition . Link to PR thread where there are some slides https://forums.phoenixrising.me/index.php?threads/video-mutations-in-energy-and-autoimmune-genes-cooperate-to-cause-me-cfs-with-alan-light-phd.62439/#post-1016900
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    Prospective Biomarkers from Plasma Metabolomics of ME/CFS Implicate Redox Imbalance in Disease Symptomatology, 2018, Hanson et al

    Would low blood volume impact the functional capabilities of any of these small differences?
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    Prospective Biomarkers from Plasma Metabolomics of ME/CFS Implicate Redox Imbalance in Disease Symptomatology, 2018, Hanson et al

    I am probably being incredibly stupid, not having much biochemistry, but to me small differences are not the issue. Given the common nature of expression , surely in a system s condition it is not the individual difference s, but the cumulative effect of them that is as important? How do these...
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    Adolescent’s descriptions of fatigue, fluctuation and payback in CFS/ME: interviews with adolescents and parents, 2018, Crawley et al

    Note semi structured interviews - the framing of the topic would be interesting to see and may account for the fatigue focus and any introduction of bias; is there any way to access this ?
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    Adolescent’s descriptions of fatigue, fluctuation and payback in CFS/ME: interviews with adolescents and parents, 2018, Crawley et al

    I find it disheartening that after so many years of adolescent research, that researchers and those treating the illness have not got to grips with the basics. It is not fatigue, it is fatiguability that distinguishes things; moreover fatigue may not be the most debilitating of symptoms for...
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    Adolescent’s descriptions of fatigue, fluctuation and payback in CFS/ME: interviews with adolescents and parents, 2018, Crawley et al

    New paper - has a number of red flags. Focuses on fatigue description and " payback" as a description for PEM without much definition. Questionnaire based, pre diagnosed Mild/ moderate but not housebound I don't know if any comorbidities (OI, EDS etc) have even been thought about I have not...
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    Stanford Community Symposium 2018: Phair, Metabolic traps, Tryptophan trap

    Very interesting . Does Phair know of this ? Replication out with a severe illness group?
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