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"constant need to lie down" struck a big chord since it describes my last few years. Doctors ask about increased heart rate, dizziness, sweating, inability to stand, etc. None of that, just the overwhelming nagging urge to lie down. For me it is the subtle defining characteristic of PEM. If...

For many years I coped with 3 pots of coffee every day. I always wondered why I could drink a full pot and then go to bed an hour later. I tried modafinil for quite some time. I felt almost driven. Eventually I started doubling the dose, eventually getting to the highest dose allowed. My...

Merged thread Can autoimmune diseases be cured? Scientists see hope at last Another Nature article about CAR-T and CAAR-T https://www.nature.com/articles/d41586-024-00169-7

News article from a small local news publication. https://www.vicnews.com/local-news/life-derailed-long-covid-still-gnaws-at-victoria-long-after-pandemic-fades-7299085

"Inside long COVID’s war on the body: Researchers are trying to find out whether the virus has the potential to cause cancer" Fortune magazine https://fortune.com/2023/11/23/inside-long-covids-war-body-researchers-trying-find-out-virus-potential-cancer-carolyn-barber/

"Antiviral drugs are generally considered to be a 20th century invention. But recent research has uncovered an unexpected facet to your immune system: It can synthesize its own antiviral molecules in response to viral infections. My laboratory studies a protein that makes these natural...

"This is a good thing in the case of a viral infection, where necroptosis not only kills the infected cells but instructs the immune system to respond, clean things up, and start a more specific, long lived immune response," Dr. Garnish said. "But when necroptosis is uncontrolled or excessive...

Quercetin is a recommended supplement for those with MCAS (Mast cell activation) I've had very good success (way more energy, clarity) following the masc cell protocol (cutting histamines from diet, using H1 and H2 antihistamines). I've found that changing the antihistamines every few months...

"We found that metformin-treated individuals had less type-I myofiber atrophy during disuse, reduced pro-inflammatory transcriptional profiles, and lower muscle collagen deposition during recovery. Collagen content and myofiber size corresponded to reduced whole muscle cellular senescence and...

"In neurodegenerative diseases, microglia switch to an activated state, which results in excessive secretion of pro-inflammatory factors. Our work aims to investigate how this paracrine signaling affects neuronal function. Here, we show that activated microglia mediate non-cell-autonomous...

For me, antihistamines give me more mental and physical energy. I can sit and play a game of cards without being cranky and exhausted while waiting my turn to play. I'm much more pleasant and social. PEM has not changed at all. I try to reduce it by enjoying the highs but sticking to a strict...

I use Reactine (H1) and Pepcid (H2). Pepcid is about the only OTC H2 available in Canada. I've also found Benadryl has a good effect, though it doesn't last as long. The advice is generally to try them until you find ones that work for you. Very late in life I started becoming allergic to bee...

I've had really good success with the mast cell protocol of H1/H2 antihistamines and reducing histamine containing foods. For years I've had a bilateral forearm itch that didn't respond to any kind of medication. Now I use it as an indicator of having a histamine response after some foods...

I did a two day exercise test at a facility that usually tests athletes. When I asked if there was anything unusual in the tests the lady said that the amount of lactate I was producing was more like a young person than someone 56 years old.

https://www.nature.com/articles/s41564-023-01349-3 The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. Previous studies show...

In 2013/2014 the authors started a patent (withdrawn) for NO treatment of ME/CFS Nitric oxide donor for the treatment of chronic fatigue syndrome

One day I was standing at the grocery store checkout with a red cabbage on the scale. It didn't have a number sticker so I was trying to enter the name on the keyboard. After 5 seconds or so of not getting a name I set it aside and ran other items through. When I got through all the items I put...

"It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize innate immune signaling pathways to diversify their repertoire of effector functions is unknown. Gasdermin E (GSDME) is a membrane pore-forming molecule that has been shown to...

Last year at age 63 I discovered I was autistic. I score at the top end of the standard tests. The closest I could get to confirmation was a therapist who agreed I easily met the criteria but can't do an official diagnosis. That's expensive, time consuming and not worth the effort at my age. I...

In general, the H1 inhibitors are found as over the counter allergy medication. The H2 inhibitors are the ones that can be found in over the counter heartburn medication. Please take care to look up the ingredient given on the box to be sure they belong to that drug class. For instance...