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"Should researchers have the freedom to perform research that is a waste of time? Currently, the answer is a resounding ‘yes’. Or at least, no one stops to ask whether there are obvious methodological and statistical flaws in a proposed study that will make it useless from the get-go: a sample...

And our first official post on Mastodon, https://med-mastodon.com/@s4me/109659821777575037

Abstract Background: Aerobic exercise has a beneficial impact on physical and mental health. However, patients with fibromyalgia do not always report perceiving these improvements. Objective: The aim of this study was to examine whether catastrophic thinking moderated the effects of perceived...

Abstract Fibromyalgia syndrome (FMS) is a common condition lacking strong diagnostic criteria; these criteria continue to evolve as more and more studies are performed to explore it. This investigation sought to identify whether participants with FMS have more frequent and larger...

Introduction: Irritable bowel syndrome and fibromyalgia share similar pathophysiologic mechanisms including sensitization of peripheral and central pain pathways, autonomic dysfunction and are often co-diagnosed. Co-diagnosed patients experience increased symptom severity, mental health...

They identified 'PEM' with... "Did you experience problems with: Prolonged postexercise fatigue"

Abstract Background Limited evidence exists on sex differences in post-COVID fatigue among non-hospitalized patients. Therefore, aim of the study was to evaluate the course of chronic fatigue symptoms in non-hospitalized subjects with the SARS-CoV-2 infection, according to sex. Methods...

Of course, this uses a mouse model of tiredness, not ME.

Background: Skeletal muscles are organs with high energy requirements, especially during vigorous exercise. Adequate mitochondrial function is essential to meet the high energy needs of skeletal muscle cells. Recent studies have reported that red ginseng can significantly improve chronic...

Hi. If you can email info@decodeme.org.uk, explaining the details then they can check on this for you. As far as we know, the backlog of booking in samples at the processing centre has been cleared so we would have expected this to include your sample, if it had reached the centre. My suspicion...

Abstract Post-acute sequelae of coronavirus disease 19 (COVID-19) (PASC) describe a wide range of symptoms and signs involving multiple organ systems occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, representing a growing health problem also in the world...

"The aetiology of FND is not fully understood. Data suggest various risks, precipitant, and perpetuating factors. Previous stressful life events, including childhood or adult-life abuse, certain personality traits, anxiety and depressive disorders are significantly more common in patients with...

Abstract Recent observations suggest that autism spectrum disorder (ASD) co-occurs in people with a functional neurological disorder (FND), but little systematic data are available on the relationship between FND and autism. The study aimed to assess the self-reported autistic traits via a...

Full title: Development and Validation of a Mobile Application as an Adjuvant Treatment for People Diagnosed with Long COVID-19: Protocol for a Co-Creation Study of a Health Asset and an Analysis of Its Effectiveness and Cost-Effectiveness Abstract Objective: To analyse the overall...

Abstract Background: This study aimed to identify clusters of long COVID-19 symptoms using latent class analysis and investigate the psychological factors involved in the onset of this syndrome. Method: Five hundred and six subjects recovering from COVID-19 completed a series of standardized...

Abstract The novel SARS-CoV-2 virus and resulting COVID-19 global pandemic emerged in 2019 and continues into 2022. While mortality from COVID-19 is slowly declining, a subset of patients have developed chronic, debilitating symptoms following complete recovery from acute infection with...

Abstract Background: Heart rate variability is a non-invasive, measurable, and established autonomic nervous system test. Long-term COVID-19 sequelae are unclear; however, acute symptoms have been studied. Objectives: To determine autonomic cardiac differences between long COVID-19 patients...

Abstract Coronavirus disease 2019 (COVID-19) is characterized by a broad spectrum of clinical symptoms. After acute infection, some subjects develop a post-COVID-19 syndrome known as long-COVID. This study aims to recognize the molecular and functional mechanisms that occur in COVID-19 and...

News in Brief post for w/c 2nd Jan 2023. Facebook: https://www.facebook.com/sci4me/posts/pfbid03QehhwYSdB2uPk8k2sh2Qipv2zF6pQDfcpZpFeZqkW4dYTfTMr3YagwXzHeNTA8xl and published papers thread Facebook...

So limiting the possible pool of patients who can take part is a good thing then?