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Published papers thread for w/c 3rd April. Mastodon: https://med-mastodon.com/@s4me/110173528173412495

Abstract Recapitulating the normal physiology of the microvasculature is pivotal in the development of more complex in-vitro models and organ-on-chip designs. Pericytes are an important component of the vasculature, promoting vessel stability, inhibiting vascular permeability and maintaining...

Abstract With new daily discoveries about the long-term impacts of COVID-19, there is a clear need to develop in vitro models that can be used to better understand the pathogenicity and impact of COVID-19. Here, we demonstrate the utility of developing a model of endothelial dysfunction that...

News in Brief post for w/c 3rd April. Facebook: https://www.facebook.com/sci4me/posts/pfbid0AUZsb6gTkEeTdZ3fWnPWaC5V6L4PAk1Hi6FsTAc14DQCckgNkJ7KmmzNnbzUwAzQl Mastodon: https://med-mastodon.com/@s4me/110168951901556202

Abstract Recent studies have investigated post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) using real-world patient data such as electronic health records (EHR). Prior studies have typically been conducted on patient cohorts with specific patient populations which makes their...

Abstract Approximately 15% of adult Canadians with SARS-CoV-2 infection develop lingering symptoms beyond 12 weeks post-acute infection, known as post-COVID condition or long COVID. Some of the commonly reported long COVID cardiovascular symptoms include fatigue, shortness of breath, chest pain...

Employers must provide better support to workers with long covid "People with long covid need to be believed, trusted, and offered flexible workplace adaptations by employers, writes S Thompson A recent report by TUC and Long Covid Support highlights the challenges facing people with long...

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Background Fibromyalgia (FM) is a complex, still poorly understood, and difficult-to-treat chronic pain condition for which many people struggle to find adequate care. Aims This study investigated the research question, “What do people accessing health care services for fibromyalgia perceive as...

Purpose The long-term symptoms of coronavirus disease 2019 (COVID-19), i.e., long COVID, have drawn research attention. Evaluating its subjective symptoms is difficult, and no established pathophysiology or treatment exists. Although there are several reports of long COVID classifications...

Introduction: Although previous research suggests that overpressure exposure from either high-level blast (HLB) or low-level blast (LLB) are harmful to health, to date no large-scale studies with representative samples of military personnel have utilized prospective designs and self-reported...

Background Q-fever is a zoonotic disease that can lead to illness, disability and death. This study aimed to provide insight into the perspectives of healthcare workers (HCWs) on prerequisites, barriers and opportunities in care for Q-fever patients. Methods A two-round online Delphi study was...

Trial By Error: What is Recovery Norway’s Role in the JAMA Network Open Study of Long Covid in Young People? "Undisclosed in the paper was that it was developed in partnership with a group called Recovery Norway, which identifies its members as “people who have experienced recovery from ME/CFS...

"The origin of a distinctive BRCA1 gene variant has been found during the Orkney islands disease study, ‘Orcades’ A BRCA1 gene variant that increases the risk of breast and ovarian cancer originates from the Orkney islands, according to research published last month in the European Journal of...

CASE: Adam is a 14-year-old adolescent boy with hearing loss who presented to the pediatric neurology clinic accompanied by his father for evaluation of new-onset left hand tremor for a duration of 1 month. An American Sign Language interpreter was present and used throughout the visit. Adam...

Purpose This study describes long COVID symptomatology in a national sample of 18- to 20-year-olds with Polymerase Chain Reaction (PCR)-confirmed Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and matched test-negative controls in England. Symptoms in 18- to 20-year-olds were...

Abstract Factors influencing SARS-CoV-2 antibody dynamics, transmission, waning and long COVID-19 symptomatology are still not fully understood. In the Danish section of the Novo Nordisk Group, we performed a prospective seroepidemiological study during the first and second waves of the COVID-19...

Background: Different SARS-CoV-2 variants can differentially affect the prevalence of Post Covid-19 Condition (PCC). This prospective study assesses prevalence and severity of symptoms three months after an Omicron infection, compared to Delta, test-negative and population controls. This study...

Alan Carson, of FND fame, supporting "properly conducted" trials of exercise for Long Covid. "Despite the anxiety it remains case that no randomised trial or systematic review of trials has ever shown harm from exercise in PEM- whilst NICE often cited it did not find any RCT evidence of harm...