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That's the million dollar question if this is actually happening. As far as I am aware a few possibilities are: reduced cerebral blood flow, some issue with the glial cells becoming sensitized themselves, an excess metabolite, signaling from other parts of the body through things like the Vegas...

The study itself showed that these psychiatric diagnosis had no impact on the measured parameters. What is more interesting to me are the differences between the ME and control patients.

It is also very hit-and-miss for me. Several times I have drank a coffee and spent the next twelve hours throwing up with terrible headaches. Other times it doesn't do much at all. I learned it isn't worth the risk but I wonder why there are a variety of responses.

Yeah that's about right from what I remember. I gave my samples about a year ago when I was still living in NYC. I'm surprised a preprint hasn't come out yet but maybe I was one of the first participants.

There are these two studies that I have recently found. https://www.s4me.info/threads/ventricular-cerebrospinal-fluid-lactate-is-increased-in-cfs-compared-with-generalized-anxiety-disorder-2009-mathew-et-al.36734/#post-509948...

They state that: "Considering all these results together, it can be stated that there are widespread metabolic changes in many brain regions compared to healthy controls, in addition to hypermetabolism in PCC." "There are two interpretations of this result; firstly, the hypermetabolism in PCC...

That is a good point. For me episodes of PEM have always been on the shorter side, but there are certainly those where PEM lasts longer then metabolites would stay in the brain. One possible solution is that excess metabolites trigger different problems in the brain which can then last longer...

Jarred Younger presented some preliminary unpublished lactate data during the ME/CFS Research Roadmap series. It seemed to have a similar distribution to what they found in this paper; that there is overlap between HC and ME/CFS but a higher average and some patients with very clearly abnormal...

I'm curious where the issue with this logic is: Any theory of ME/CFS should explain why PEM from cognitive exertion occurs. At the most basic level the biological impacts of cognitive exertion are the use of additional energy and the production of some metabolites. Therefore, there has to be an...

Yup exactly, sounds like I experience the disease in a similar way to you. If this were the case there is also likely to be multiple different paths into a pathological state. Resolving the issue could very well require different things in different people.

Thanks, seems like a good list. You'd think these hypothesis wouldn't be that hard to test, I guess it just takes money, time and some rigorous trial protocols that have been lacking. Doesn't seem like immune modulating drugs, mestinon, or nicotine has been that effective. Also I meant to say...

Interesting. What are the alternative hypothesis for blood pooling in the extremities in POTS again? I know SFN is a potential cause but is there anything else?

Thanks for posting this SNT. I do think a process like this could explain why cognitive overexertion would produce PEM. If the exertion produces toxic metabolites that can't be cleared quickly in ME/CFS, then one might expect a poisoned feeling, noise and light sensitivity, headaches, vision...

I wanted to know if other pw ME/CFS experience any sort of paresthesia and what the possible causes are. I have had tingling and hypersensitivity to touch primarily in my left torso, leg and arm for around 7 years now. I believe the tingling was a result of a sports injury to my back, however...

Summary graph illustrating the vicious cycle linking research funding from vested interests, poor science, and limited accountability

The purpose isn't to ban anything, the purpose is to discover the truth and help improve the lives of patients. If psychological research were likely to lead to answers or provide treatments, I would be all onboard. However, it is demonstrably the case that psychological research has had the...

I submitted this comment: Funding for Researchers working on the Biological Basis of ME/CFS The NIH needs to make it clear, that only researchers working under the assumption that ME/CFS is a biological disease will be funded or supported. We should not tolerate those individuals who wish to...

I think it's more complicated to accurately measure it than what's commonly done. My understanding is typically the velocity of the blood is measured (as this is easy to do) but this can differ from volume of blood flow to the brain. I also have had it measured by your average neurologist and it...

Compare this to the NIH study. In controls, the NIH that found 3/17 (17.6%) had OH and 7/17 (41%) had symptoms. The methodology might have been different, but that is a huge difference from the 10% of controls that had asymptomatic OH and 0% that had symptoms in this study. How did the NIH...

Or even better, do the quick easy task and fail it so it doesn't go into the pool of rewards :sneaky: