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  1. leokitten

    The symptom signaling theory of ME/CFS involving neurons and their synapses

    Has it been ruled out that ME could be an antibody mediated disorder? Sorry I’m out of the loop thought novel autoantibodies are difficult to discover without already having some idea of what you are looking for ahead of time.
  2. leokitten

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    From my understanding GWAS findings by themselves aren’t causal only correlative. You need to perform additional analyses to do casual inference. See for example an explanation here https://pmc.ncbi.nlm.nih.gov/articles/PMC7614231/
  3. leokitten

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Right but the underlying goal of a genetic study like this is to gain some mechanistic insights as to what triggers or continues to drive the illness, and if the genetic component/influence is very low then these gene variants more likely than not do not play a major role in the pathomechanism...
  4. leokitten

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Right and if true a very high predominance of non-genetic influence, whether stochastic or epigenetic, would further suggest that it’s potentially quite limited what mechanistic insights we might glean from additional genetic studies.
  5. leokitten

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Does anyone know what is the genetic vs environmental influence they’ve estimated for ME given these new GWAS results? I swear I read somewhere that it’s estimated to be only a ~10% genetic contribution? Can’t find the source again And if it’s predominantly environment that influences ME...
  6. leokitten

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Did they publish the rsIDs for the loci within these eight genes? We could then look them up on snpedia.com
  7. leokitten

    Hamsters with long COVID present distinct transcriptomic profiles associated with neurodegenerative processes in brainstem 2025 Coleon et al.

    Golden hamsters are a commonly used animal model to study COVID. You will find them used as a robust preclinical model in a lot of studies https://www.pnas.org/doi/10.1073/pnas.2009799117
  8. leokitten

    Long-term outcomes of mesenchymal stem cell therapy in severe COVID-19 patients: 3-year follow-up of a [RCT], 2025, Yuan et al

    Didn’t they probably use allogeneic (not autologous) MSCs that have far lower risk of immunogenicity and rejection?
  9. leokitten

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Maybe there’s some kind of CD38 targeting CAR-NK or CAR-T cell therapy that can better target and deplete CD38 plasmablasts while sparing CD38high NK cells and retaining sufficient ADCC cytotoxicity. Would really help test their theory and see if better responses can be produced in the lower NK...
  10. leokitten

    International ME/CFS Conference 2025 Berlin May 12-13

    In the YouTube presentation above listen starting at 5:30
  11. leokitten

    International ME/CFS Conference 2025 Berlin May 12-13

    @Jonathan Edwards you’ve stated repeatedly that RituxME trial results showed that B-cell depletion doesn’t work for ME. Fluge and Mella (and I in previous responses to your comments) disagree they said in their presentation that indeed for a subset it does work. What are your thoughts on this?
  12. leokitten

    International ME/CFS Conference 2025 Berlin May 12-13

  13. leokitten

    Brainstem Reduction and Deformation in the 4th Ventricle Cerebellar Peduncles in Long COVID Patients, 2025, Christof et al

    I agree, but also this study and possibly others found probable white matter track damage in these brain areas as well via fractional anisotropy DTI measurements.
  14. leokitten

    Brainstem Reduction and Deformation in the 4th Ventricle Cerebellar Peduncles in Long COVID Patients, 2025, Christof et al

    These kind of studies and hypotheses are intriguing to me because this could also possibly explain why CCI/AAI surgery produces remission in some and possibly why LDA ie partial dopamine agonists significantly help others since the cerebellar peduncles play a very important role in the brain’s...
  15. leokitten

    Brainstem Reduction and Deformation in the 4th Ventricle Cerebellar Peduncles in Long COVID Patients, 2025, Christof et al

    https://www.medrxiv.org/content/10.1101/2025.04.08.25325108 Abstract Post-COVID Syndrome (PCS), also known as Long COVID, is characterized by persistent and often debilitating neurological sequelae, including fatigue, cognitive dysfunction, motor deficits, and autonomic dysregulation (Dani et...
    • leokitten
    • Thread
    • brain imaging brainstem cerebellum demyelination diffusion mri diffusion tensor imaging long covid myelin
    • Replies: 21
    • Forum: Long Covid research
  16. leokitten

    A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID, 2025, Bader et al

    https://www.nature.com/articles/s41467-025-57905-4 Abstract The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has highlighted the vulnerability of a globally connected population to zoonotic viruses. The FDA-approved coronavirus antiviral Paxlovid targets the essential SARS-CoV-2 main...
  17. leokitten

    List of diseases with a known mechanism but no cure/treatment

    I think it goes without saying that everyone here in favor of doing treatment trials without already having an established mechanism are not in favor of just trying things randomly or based on a hunch with little evidence. For sure we would want to have preliminary evidence pointing in a...
  18. leokitten

    List of diseases with a known mechanism but no cure/treatment

    I think the lists that were provided were meant to highlight some examples to get us thinking not some kind of comprehensive work. Also I don’t think jay meant abandoning mechanistic work in favor of trialing treatments, just that treatment trials even without an established mechanism...
  19. leokitten

    Impacts of the 2024 change in US government on ME/CFS and Long Covid

    Scientific American: COVID Research Funding to Be Slashed, NIH Documents Show
  20. leokitten

    USA: The RECOVER Initiative - Long Covid research

    Scientific American: COVID Research Funding to Be Slashed, NIH Documents Show
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