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Abstract for a poster presentation made at the British Journal of General Practice. Background Treatment-resistant depression (TRD) is when antidepressants do not work and affects 55% of British primary care users with depression. People with TRD should be referred to secondary care but there...

Abstract for an oral presentation made at the British Journal of General Practice. Background Restrictions due to the COVID-19 pandemic resulted in a sudden shift to a predominantly remote consulting model in primary care from March 2020. Little evidence exists examining the experience of...

Traumatic brain injury (TBI) is a global health priority, associated with substantial burden. Historically conceptualised as an injury event with finite recovery, TBI is now recognised as a chronic condition that can affect multiple domains of health and function, some of which might deteriorate...

Posting just because I can't believe that they created a disorder out of grief.

Background Prolonged Grief Disorder (PGD) was recently included as a disorder in DSM-5-TR despite some controversy. The rate of PGD is known to vary according to a number of factors and little is known about how bereaved individuals view the diagnosis. Methods This cross-sectional study...

Dr Mark Faghy on Twitter, "A thread for our new research project looking at Post Exertional Malaise/Post-Exertional Symptom Exacerbation in #LongCovid" https://threadreaderapp.com/thread/1680882026717536256.html

"Why have we chosen to study physical exertion? We know that PEM and PESE are brought about by mental and emotional exertion as well as physical exertion and this is something that we also need to increase our understanding of. To better understand PEM and PESE we first need to look at the...

"The value of clinical cardiopulmonary exercise testing (CPET) within healthcare settings has been established in the last decade. CPET methods remain highly relevant in the COVID-19 endemic phase and should be used to assess those recovering from COVID-19 infection. This diagnostic tool could...

Can't know if these are what they are referring to but there are these studies (neither of which we have a thread for) "patients presented increased proportions of Lactonifactor and Alistipes, as well as a decrease in several Firmicutes populations."...

2022/23 annual report available, https://worldmealliance.org/2023/07/celebrating-growth-collaboration-and-impact/

I am, but really only for the heart rate variability reading, which seems to have no relation to how I am actually doing, and resting heart rate reading, which seems to have some. I don't pay any attention to the 'stability score', it seems unable to reflect how I'm feeling.

Abstract Patient and public involvement and engagement (PPIE) can provide valuable insights into the experiences of those living with and affected by a disease or health condition. Inclusive collaboration between patients, the public and researchers can lead to productive relationships...

"Patient-led start-up Visible has launched two app-based health studies in collaboration with researchers at Imperial College London. Since it launched in November 2022, over 30,000 people with Long COVID or myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) have been using the...

Editor’s summary Patients with heart disease frequently present with low melatonin levels and show disruptions in their sleep–wake cycles. Although disordered sleep adds considerably to the overall disease burden of these patients, the mechanisms that underlie this phenomenon remain unclear...

Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like T lymphocytes with tremendous antibacterial and immunomodulatory functions. Additionally, MAIT cells sense and respond to viral infections in an MR1-independent fashion. However, whether they can be directly targeted in...

(Merged) Final paper - paywall Extensive research links regular physical exercise to an overall enhancement of cognitive function across the lifespan. Here we assess the causal evidence supporting this relationship in the healthy population, using an umbrella review of meta-analyses limited to...

Pre-print (free access) Abstract Extensive research links regular physical exercise to an overall enhancement of cognitive function across the lifespan. Here, we assess the causal evidence supporting this relationship in the healthy population, using an umbrella review of meta-analyses limited...

Agree with whom? I was making the point that there is no evidence that the major charities aren't willing to work together, or that they think that small projects are the most likely way to bring about substantial change.

"And we need our charities to understand that we're not likely to achieve a research breakthough through small, charity-funded research projects." Personally I feel that is misrepresenting our charities. Is there any evidence that they believe that we are "likely to achieve a research...

Trial By Error: Psych Medicine’s Non-Responsive Response to a Request for Correction of Prevalence Rates Cited in FND Paper "I have recently sent out a few letters to major journals seeking corrections in articles that have mis-reported the estimated prevalence of functional neurological...