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Abstract Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo...

Highlights Menopause is associated with changes in sex hormones and the immunological profile which may impact MS disease course. Conflicting evidence on the impact of menopause on MS remain an important gap in the literature. Understanding the impact of menopause is critical for reducing...

Translation: We don't want to invest in basic research, we'll wait for others to do the work first.

Moderna is eyeing a new target: long Covid. The pharmaceutical company that became a household name when it developed a Covid-19 vaccine now wants to treat the disease’s lingering effects, which have afflicted tens of millions of people by some estimates. “We see this as an opportunity for...

We have a thread on inspiritol A member did post a pic of a duck.

This new study just showed up on my X feed. Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss LINK Bone-Enhancing Peptide Shows Promise as Therapeutic for Osteoporosis and MSK Disorders LINK

That link to Better Bones has got a lot woo in there. Link between Fear and Bone. "Emotions and Bone Strength: Are the "Winds of Worry" Weakening Your Bones?"

There is also another issue that I've encountered years ago. My magnesium levels were below normal, mg is needed to move vitamin D around in the blood to activate vitamin D (1.,2, dihydroxyvitamin). Most GP won't test for this particular vitamin D unless you have hypercalcemia. Mine did...

I've been taking vitamin K2 (MK-7) with vitamin D for the last 6 years. There are conflicting studies that show vitamin K2 helps with bone health but I can't say for certain whether it helps or not. I just continue taking it.

The researchers believe their treatment can reach clinical trials in just five years. We break down how it works. Strong and his team’s most recent breakthrough came after discovering that a tiny, specific fragment of RGNEF was able to mitigate the toxic effects of TDP-43. This fragment...

Fixed

Shehla Ali from About ME looks at the racism and discrimination that pervades healthcare for South Asian women living with ME. What is Bibi/Begum Syndrome? Medical terminology used to gaslight South Asian women, predominantly those who are elderly ad may have a language barrier. LINK

I only visit these threads for the one-liners.

Groups representing UK sufferers are “very disappointed” as the US recently allocated another $515 million in research funding for what it called an “urgent healthcare crisis” LINK

The M.E specialist I saw in 1991 based his assessment on onset, history, r/o other causes and relapses. The diagnosis was not made based on symptoms.

"But the nature of the biological evidence remains contentious. Jeffrey Winters, a pathologist and chair of the division of transfusion medicine at the Mayo Clinic, said the way Pretorius and Kell describe amyloid clots is confusing to scientists who view amyloids in a different context. “I...

About 85 teachers in the UK have expressed an interest in joining the action LINK

Blurry vision is my first indicator and when my equilibrium starts to shift. It's not what I would describe as PEM, but I know I need to lie down soon.

I don't know if I got EBV when I became ill in 1991 during sudden viral onset. I did not have fatigue, PEM or cognitive issues for years. I had vertigo and other symptoms and felt 'flat' after exercise. I was still functional for months until I was vaccinated with Hep B and that's...

Highlights Digital biomarkers predict fatigue ratings continuously throughout the day Physical and ANS activity while awake and asleep relate to fatigue ratings Dysfunction of the ANS alters the effects of biomarkers on fatigue ratings Summary Fatigue is the most common symptom among multiple...