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Abstract Cerebrospinal fluid (CSF) is responsible for maintaining brain homeostasis through nutrient delivery and waste removal for the central nervous system (CNS). Here, we demonstrate extensive CSF flow throughout the peripheral nervous system (PNS) by tracing distribution of multimodal...

This was from 2016 Meet the Scientists: Dr Menon Now that the US Agency for Healthcare Research and Quality has downgraded the conclusions for graded exercise and cognitive behavioural therapy (and the PACE trial methodology has been found wanting by scientists in the field), do you think more...

Summary Background Spontaneous intracranial hypotension (SIH), characterized by headaches due to cerebrospinal fluid leaks or low pressure, is a challenging condition to diagnose and treat and affects the quality of life. Methods An 8‑week online survey was conducted to assess the impact of SIH...

Abstract Cardiopulmonary exercise testing (CPET) is a comprehensive and invaluable assessment used to identify the mechanisms that limit exercise capacity. However, its interpretation remains poorly standardized. This scoping review aims to investigate which limitations to exercise are...

Highlights Chronic SF impairs glucose metabolism and cognitive performance in mice Hypothalamic acetate levels are adaptively elevated in response to SF Acetate mitigates dysglycemia, cognitive impairment, and inflammation in SF mice Acetate binds and activates PC to restore glycolysis in...

@duncan I was referring to this https://igenex.com/wp-content/uploads/western-blots-vs-immunoblots-igenex.pdf

This is an issue for pwRA.

One of the contact persons is Dr Ranjit Menon, a psychiatrist who specializes in mood and anxiety disorders, Sports and exercise psychiatry. I'm herxing already.

Looks like ImmuneBlot replaces the Western blot which is blurry and difficult to interpret and leaves patients with a questionable dx. Certainly a big improvement for patients :emoji_thumbsup:

We have a thread on the Bornfree protocol here

Abstract Long COVID is a novel emerging syndrome known to affect multiple health areas in patients previously infected by SARS-CoV-2 markedly impairing their quality of life. The pathophysiology of Long COVID is still largely poorly understood and multiple mechanisms were proposed to underlie...

Abstract Lyme disease, caused by Borrelia burgdorferi (Bb), can progress to Lyme arthritis (LA). While most patients with LA respond successfully to antibiotic therapy, a small percentage fail to improve, a condition known as antibiotic-refractory Lyme arthritis (ARLA). While T cell responses...

Abstract Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains...

Summary Background Children can develop Long Covid, however long term outcomes and their predictors are poorly described in these patients. The primary aim is to describe characteristics and predictors of Long Covid in children assessed in-clinics up to 36 months post-SARS-CoV-2 infection, as...

The technique could help researchers understand how diseases change the body LINK Achieving optical transparency in live animals with absorbing molecules, 2024, Zihao Ou et al LINK

Moved posts I was going to present this Lightning Talk at the Stanford ME/CFS research meeting tomorrow, but due to a last minute shake-up, I won't be able to. So I'll present it here. @RenegadeRes Credit to @tessfalor for slide template. 1/n

Abstract Epstein-Barr virus (EBV) infection has long been associated with the development of multiple sclerosis (MS). MS patients have elevated titers of EBV-specific antibodies in serum and show signs of CNS damage only after EBV infection. Regarding CD8+ T-cells, an elevated but ineffective...

Influence of mRNA C-19 vaccine dosing interval on the risk of myocarditis, 2024 Abstract Myocarditis is the most salient serious adverse event following messenger RNA-based Covid-19 vaccines. The highest risk is observed after the second dose compared to the first, whereas the level of risk...

No way! Ugh ME/CFS is not 'mechanical'.