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Full title: Neutralization of Autoantibodies Targeting G-Protein Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms after COVID-19 Infection Abstract Clinical features of Corona Virus Disease 2019 (COVID-19) are caused by the severe acute respiratory syndrome coronavirus-2...

I wouldn't discount the sustained unusual posture associated with a car journey, nor the activities surrounding getting into the car in the first place. It took me many years to realise that a great deal of the impact of traveling somewhere was in fact related to the unusually timed &...

No problem at all @Jacob, I wish you luck with whatever you choose. Do keep in mind that you won't get very far with local care, usually you need to target specific doctors at teaching hospitals to find people willing to take on complicated patients - from my experience and from most reports I...

Hi @Jacob Richter, In my experience getting these sorts of investigations done (or anything, really) won't happen with ME/CFS as the indication. Best to leave that diagnosis at the door and focus on the specific problems. I've no experience going down this route with a Fibromyalgia diagnosis...

I had a similar experience in one of my three CPETs. RER @AT was 1.1, RER @VO2max was 1.5! It was a poor result, 50% of expected VO2max. I was unknowingly hyperventilating with a clear breathing pattern disorder. I confused the heck out of the technicians because my breathing rate was low but...

Waiting very impatiently for this: The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome - Full Text View - ClinicalTrials.gov :)

I wonder if these ideas come from well established counter-manoeuvres for combatting OH and high G training, which involve engaging various groups of muscles. We also know that abdominal compression can change hemodynamic parameters too. I was curious if there was anything else out there and...

From the video:

Presentation from Dr Cyndya Shibao including apparent early data from an unpublished pilot study into autonomic regulation of glucose in POTS. Very interesting video for those of us here that experience postprandial (after eating) problems, I know these issues have been discussed a fair bit...

Being written in 2012, this is showing its age. To give an example of one outdated assumption made in this paper: In 2014 we had this study: REDUCED CEREBRAL BLOOD FLOW WITH ORTHOSTASIS PRECEDES HYPOCAPNIC HYPERPNEA, SYMPATHETIC ACTIVATION AND POTS (nih.gov) But aside from that specific...

Unfortunately I've heard similar reports from patients attending a major teaching hospital autonomic unit in London - they catch POTS patients because of the nature of their clinic and probably only because they are forced to. They aren't the least bit interested in understanding or treating...

There's a fair bit of research in the field of POTS going back 20 years into questions like this, sub-groups were even identified depending on the blood flow and pooling types. They used a variety of methods to make these sorts of measurements, from memory certainly plethysmography, I think also...

Suspect there may be concerns over tolerance - I often see complaints from patients saying the high salt intake creates GI problems. Perhaps the investigators felt it better tolerated with meals.

It was reported that this article will be free to read for a limited time - perhaps only after the journal publication date in May? Anyway, the images seem to be there and with a bit of sneaky thumbnail renaming you can see: ------------------------ ------------------------...

Could they have measured total blood volume separately to plasma volume? They refer to them as separate variables at the start of the results paragraph.

Good to see further studies offering evidence for long-held assumptions/observations in POTS treatment. High profile journal too. Haven't been able to find full-text yet but there's an editorial on the paper from Blair Grubb: High Sodium Intake in Patients With Postural Orthostatic Tachycardia...

Abstract Background High sodium intake is recommended for the treatment of postural tachycardia syndrome (POTS) to counteract the hypovolemia and elevated plasma norepinephrine that contribute to excessive orthostatic tachycardia, but evidence of its efficacy is not available. Objectives This...

I'm in no position to comment on the validity of the science but one of Fedorowski's more recent videos discusses how viewing these antibody tests in isolation is worthless, little to no difference with HC. Instead he suggests combination scoring shows the significant difference between POTS and...

Some of these GPCR autoantibodies have been found in a majority of POTS patients previously. There's been similar studies in broader CFS with weaker findings. The autoantibodies have been shown to be pathogenic in other diseases but their exact role in POTS isn't yet understood, there is a...

From the study: