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I think the most forgotten " hole in the energy bucket" to borrow the Myhill phrase is the emotional one. It is so difficult to predict or plan for this and it can have huge effects. My severely ill aunt's s labrador is 13 and literally on her last legs. Everyone knows that the inevitable...

Saw this on Twitter Designed for menstrual cramp - brilliant for pain relief for so many conditions Hope it is mass manufactured soon https://news.engineering.utoronto.ca/this-ultra-thin-hot-water-bottle-could-help-ease-menstrual-pain/

It's the concept of fatiguability that seems so hard for people to grasp Fatigue is not the most onorous nor annoying symptom and yet it is the most quoted / first symptom on a list. Why?

Brilliant again. Well done and thank you. Xx

Many different chip versions affect which Gene's are picked up. To be robust chip version may need defined?

Sadly this is potentially evidence base for NICE. Similarly the n=1 account of intensive therapy for a teenage boy with severe ME which reads like torture. There is very little biomedical research for paediatric/ adolescents. A muscle study which Tymes Trust were involved with ( Dundee uni) ...

And here we have Gigi facing the same fate.

Referred pain diagram may help. Also, given the recent metabolonic research , could maybe be due to.purines?

Perhaps one for Gigi would work - very simple, concise and no ambiguity.

The problem is that the methodology goes wider and affects many more conditions and careers. When it comes to eminence, the pace of change in UK is slower than a snail's .

I think.one of the most compelling pieces of advocacy was @Emsho ' s testimony at the Scottish parliament, particularly the part when she describes GET ( walking in and wheelchair out and being considered recovered) If someone has the technical skills to snip the video to this part as a reply...

Is the old boy network working overtime? Pinker was in uk recently ( he did appear on a TV panel show and was not particularly impressive) For a specialist in language nuances should really be better understood.

Great video. Will share widely . Thanks @Adam pwme

Oh to have been a fly on the wall at the safeguarding seminar earlier this year/ late last year. This may account for much as FII seems to have ramped up since. We touched upon it in a thread CFS was a designated subject , delivered by someone from Bath/ Bristol ( name escapes me - Rachel?)...

Has the role of NO linked gene expression been considered relative to instigatng bistability in IDO1/ IDO2 pathways? My understanding is that NO inhibits IDO activity by preventing oxidixation of TRP Is this a link to the sepsis similarities?

interesting link to roles and mechanisms of IDO 1 , IDO2 and TDO https://pubs.rsc.org/en/content/articlelanding/2017/mt/c7mt00105c#!divAbstract

I hope I have not mislead/ confused. I don't t know if Craig Robertson has pitched this molecularly. It simply strikes me as an explanation for the relapse and remitting aspect and the similarities re catastrophe/ instability are striking, even to a non mathematician. Interestingly similar...

Sort of like inverse obesity with grehlin and leptin signalling gone awry?

Does " Montgomery v north lanarkshire" ruling apply to physios ? The physio we saw was completely uninformed re ME, conflated with chronic fatigue, no knowledge of use of hear monitors, oi issues, what PEM actually is. When is lack of knowledge a defence when there is so much info outside their...

Microchips for alzheimer's- interact with heating system and avoid use of manual controls to provide suitable temperature - this has already been proposed (!) ( my cousins daughter has her art masters portfolio on a microchip in her hand - her theme was cybernetics) Smart meter data has...