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Didn't we see somewhere that CLOCK expression is dysregulated in pwME? Does anybody know more about that and if the mode of action of agomelatine mechanistically could have a positive influence on us in that regard?

That would definitely be something to look into further. As a starting point it sounds pretty good that they didn't observe adverse effects. I could imagine if 30 ME/CFS patients take Adderall for three months, there would be adverse effects?

Unfortunately, it's not available in the US, which surely hinders adoption/testing. I will ask my doc whether it could make sense to test it.

Low dose amisulpride (as used here) could work similarly to low dose aripiprazole if dopamine receptors play a role?

Fulltext translated from Russian with DeepL. Prospective observational trial from 2024 of post-COVID depressed patients. Only adding it, as it was mentioned in the talk.

From what I've been able to gather on agomelatine, it's a bit debated whether it really shows any 5-HT2C antagonism at clinical doses. The ki for the MT receptors are subnanomolar, where the ki for 5-HT2C is an order of magnitude higher. But apparently MT-2 and 5-HT2C form heterodimers, so...

They briefly mentioned this paper and a Russian one in the ME/CFS conference in Berlin, I just found the video. From around minute 6:15! This is the other paper he mentions in his presentation. Observational study on depressive episodes after COVID - includes a 10 point improvement in...

Fulltext can be found on sci hub.

Here's an excerpt regarding blinding:

Just saw this on Reddit and realized it apparently hasn't been shared here.

Chronic Fatigue Syndrome (CFS) represents a disabling condition characterized by persistent mental and physical fatigue, bodily discomfort and cognitive difficulties. To date the neural bases of CFS are poorly understood; however, mono-aminergic abnormalities, sleep–wake cycle changes and...

Does this exclude men with me/cfs from the hypothesis?

Just a boring update: It's still working very well. Standing around 80 BPM now (from 120-140 bpm before treatment) - quality of life greatly improved.

From what they told me, you must be in the Norwegian Health Care system, hence the requirement to be a resident. I'm not sure how quickly one could enter that. They did not tell me any language requirements, I don't think you have to be/speak Norwegian from that they told me.

Jak/Stat is a (the?) downstream signalling pathway of gamma IFN - I guess that would tie in with Jonathan's hypothesis.

This must be a typo and should probably also be 6 mg/week?

Unfortunately, only patients residing in Norway can participate.

Has anybody tried this or looked into this further?

Yeah, no idea what that is supposed to mean! Yes, the "T-cell engager" part I mention in my first post is referring to the CD3 part :) I can't speak for anything else you said regarding safety, potency or tissue penetration. I haven't look into it.

As somebody has shared a picture of a poster in another thread, I am linking the .zip of all posters.