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@DMissa If you have questions and the answers might be relevant for your work the Stanford profile for the lead author Vishnu Shankar has contact info (link to Stanford profile).

Yeah, that does not work for me either. lol at just rolling over in bed. Some people have no idea what we go through. I use a number that seems workable for my situation and not have the alarm go off all the time. The alarm I have has a delay - I have to be over the threshold for X mins.

The author of the comment has published a lot on IL-37 so I'm not surprised he suggested IL-37. (Link) Regarding MTORC1 it may be interesting to look into data for diseases that have elevated MTORC1 action in B cells to see if there is something that can be used to refine the hypothesis. I...

@DMissa In the years that have passed since this paper was published did you get any good feedback on mtor in ME/CFS? Mtor/rapamycin seems to be really hyped right now but with very little quality data, and when I asked around in 2019 I got the impression that unpublished work did not indicate...

100% agree. I wish it was possible to give out gold stars to a post @Hutan as it deserves it.

Note on Funding, reformatted for ease of reading.

I agree with a lot of what you say @Hutan. I'd just like to point out that this was funded by Canadian donations and OMF has only one Canadian research center. In the OMF financial reports major donations are often specified for a particular purpose. That may or may not be the case here, but...

I base the comment on things like this showing MFI-20 for reduced activity, Female left, male right. How on earth 10E-4 for female? In the real world there is almost no difference in activity (delta of 1.3)

Here is the supplementary data attached. I've separated out Table S3 - Symptom scores split by SMPDL3B plasma levels. A wee bit underwhelming to say the least. What I don't get is why you hide away a supposedly main finding in supplementary info yet keep the conclusion in the abstract.

I think we need to remember OMF is a non-profit/charity, that funds researchers (they are basically a few very highly paid VP's). OMF as an entity doesn't control what is written in papers, how could they. Prof Alain Moreau's team led and reported on this work. I don't know how much say other...

For those interested in IFNγ there was a difference in CMV seropositive individuals, but it was across all groups. Does this mean in the JE hypothesis we might expect enhanced effect in those with CMV seropositivity despite no relation to severity or could this be some negative data against the...

Small changes in ME/CFS T-cells compared to other groups. I've no idea what these cell types are (EM & TEMRA cells). [No figure included here because it is not legible]. It seems MAIT cells that express CD8 are more common in severe ME/CFS, similar to that seen in MS, but different from...

The video transcript in the post I linked describes antibodies to things not encountered in nature. That falls within your description I think.

For reference, Jackie Cliff recently presented some findings on the latest work at a CureME webinar earlier this year (Link to post with video). I wondered what could be the reason severe ME patients do not show a correlation between anti-HHV6B antibodies and cytotoxic Tcell activity but...

In case it helps, I posted about it on the hypothesis thread (link) and on the 2020 thread for Lipkins B cell IGHV3-23/30 paper (link)

I was shocked when I saw the label too. Figure 2 (SMPDL3B levels) looks very underwhelming, perhaps skewed by birth control. In Figure 3H, the LPS dose response curve is up and down. In Figure 4, a lot of the dose response curves are not linear???? In Figure 5, some of the vehicle...

Some background from the forum. First mention on the forum of SMPDL3B is on the Stanford working group meeting in 2020. @Ravn found the slides starting at slide 14 (link) (link to thread) Professor Alain Moreau presented on SMPDL3B in IMEC15, 2023, at 18:19 (link to thread)

From Google AI Could this be a link to the Beetjes et al Biobank findings of altered glucose and insulin signalling?

This is the OMF project page for the Medusa study for this paper. https://www.omfcanada.ngo/mecfs-adaptive-therapeutic-solution-platform/

16:12 Antibodies transferred from Long Covid to mice caused some symptoms. When they sectioned the mice they found that the antibodies were bound to nerves. Studies are about to be published on this (currently preprint). Does anyone remember that finding about antibodies binding to nerves?