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Thanks for the breakdown of the results in the paper. For something this detailed in a pilot study I think it's hard to have many samples. In the recent Stanford Vishnu Shankar paper they were able to add more samples between preprint and publication. It sure would be nice given the promising...

I've been wondering how the subgroup with IBS plays into this hypothesis. In some people could the junk IGG antibodies include ones related to food, and that kicks off a chain reaction causing IBS and food sensitivities? Since we found out this week that mast cells have FcGRI receptors, and mast...

Here is an article about "Mast cell Fcγ receptors (FcγR) for IgG" in case there is some useful information there. It also has references. https://embrn.eu/mast-cell-fc%CE%B3-receptors-fc%CE%B3r-for-igg/

Since they were researching FM and pain, and mention mast cells locating around nerves, why doesn't anyone consider the fact that mast cells also secrete GranzmeB, which is cytotoxic, as a possible cause. I'd really like to see researchers do some quality characterization of mast cells in much...

Do you think this describes what we are talking about.

@forestglip provided a great example of looking up a gene and searching how it relates to published studies etc. I'm sure Dr. Karl Johan Tronstad would love to learn about the gene link to the M3 subtype in his study that was found. Here is the post...

I think anyone can play this game. You just need to be able to search the internet, ask questions to AI, read up on Wikipedia and GeneCards, and see if any of that links to ME/CFS data or hypotheses in papers. And most of all, don't worry about what you don't know. Just like we would do for any...

So perhaps at the end of the day it comes down to people. There are a relatively large amount of not very competent people in every walk of life, or said another way, a bunch of very average people who we'd prefer they think a bit more about what they are doing and what it means. The best...

Some of the discussion seems to be about how the engineering industry uses checks, tests, and reviews to make sure projects stay on track and are reliable. Does this seem to be missing in some medical research areas? In Engineering I even had a project cancelled and re-specified which I thought...

This paper explains the method and how the Tru-culture system compares to conventional PBMC methods Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study.

More info on the Tru-culture test used in this paper in the video of a post on the Prusty paper thread. LINK (Ian Lipkin 2019 presentation to the CDC)

On the Prusty paper thread @cassava7 quoted a section of the paper where they looked at LPS stimulation.

I remember Dr. Bhupesh Prusty also did culture experiments with a couple of virus (HHV6 and flu perhaps?) and noticed a clear difference in response between ME/CFS and Control. I remember the presentation but but not whether it was published. It would be nice to compare the two experiments -...

It makes me wonder how long this study has been running and if this was a wrapping up of a long term project. Dr Montoya left Stanford in 2019, and I've not heard of recruitment for exercise studies at Stanford or by Montota for a long time. I think it could be this study that @Simon M wrote...

I think the biggest thing missing from much of research compared to engineering is focus on the priority tasks. I worked in both R&D and Engineering design and in R&D and the latter took forever to get things done. In retrospect we spent a lot of time thinking and talking, Being "creative"...

Could you guys be thinking of this Klimas study Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome We have a thread here...

In the 2018 video presentation pregnanolone was described as a neuroseteroid that can have synaptic functioning and is made in the mitochondria.

Jonas Berquist gave a short talk on targeted steroidomics at the 2018 Stanford Symposium that used 24 ME/CFS and 24 controls. Perhaps it's the same samples as this study. The only finding was pregnanolone, same as this paper. Here is the video starting at 14.59. It is 3.5 minutes in duration, so...

This is from Dr Berquists 2019 NIH presentation. I suspect they used samples from this group for several projects hoping to see if there was any cross-project links. Maybe they have been sitting on the data a long time and only now did a deep analysis after originally not finding much...

If I remember right the working groups/plan came about because of a new Minister of Health with a personal connection who was only in the position to influence things for a very short amount of time. Change in Germany happened because of a sympathetic Minister of Health who has now gone..........