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How many tried doubling the dose I wonder? For many things you cannot do that. Most drugs, some vitamins, and most minerals quickly become very dangerous if you double dose a few times over.

Bay leaf makes me worse. Spirulina makes me much worse. The original pycnogenol, made from red grapes not pine bark, had an amazing result the first time. Nothing at first. Then my stomach fizzed. Then it moved out to the entire body, like someone was carbonating my blood, down my arms and...

In 2012 I got rid of my fatigue for months, after two months of forced bed rest in hospital after I shattered my ankle and had surgery. Every other symptom remained, just not fatigue. I was also on blood thinners for those two months. Getting rid of fatigue did not equate to recovery at all. Yet...

I eat cumin a lot, but I will have to try larger doses. For non-ME reasons I take resveratrol every 3 days in moderate doses, 400-600mg. It prevents my bronchospasms almost entirely. Higher doses have persistent effects, but even higher doses are not better. In the early 90s I discovered my...

I used to write science commentaries, but once I could no longer keep a myriad of facts in my head to reason with I was done. There is a concept in computer science called satisficing a problem. Its about getting a solution good enough for all the criteria. That is what I try to do now, for the...

Its called pacing, but doing pacing perfectly is an oxymoron.

I think it is far too premature and there are way too many problems with the study. Its NOT peer reviewed. I have heard its a poster presentation. They selected people as doing time restricted eating based on two days information on food. We have no idea what their comorbidities were. We have...

This. I consider a biomarker absolutely essential for steady research progress without relying on serendipity. However there are three possibilities that present different issues. One, all or nearly all patients have the same disease, we just have not found the biomarker yet. It might be...

Let me reiterate some old biochemistry. Sleep is an active process, and the last step is to induce it by a wave of PGD2, a prostaglandin, occurring in a sequence in different parts of the brain. I have not checked to see if this biochemistry is still important in the literature, so there may...

This is what I do. Living alone I can mostly do it, but not always. It also does not work every time. However the alternatives, especially sleep hygiene. are a disaster. How many years does it take for sleep hygiene to work? I did it for nearly three years. Here are the results - chronic sleep...

Rice sticking in a bowl or device is easy if you can fill it with water. Rice sticks due to starch. Water will loosen it. I only do sink washing but everything gets soaked for a while, and I do not stand around. Indeed by doing this I can wash things much faster when I get around to it. Its the...

Saunas can be tolerated by some with ME but not if they jump in a pool at the end. Sudden cold can trigger OI and its not good to pass out in a pool. Of course I expect some would be made worse, some better, and many not find any improvement. Saunas were part of the treatment I was using in the...

I have no reason to believe we do not have increased internet usage. This is only a surprise if you dismiss our level of disability. In about 2009 I was a participant in a study on how using Second Life affects people with ME, and this was an Australian and Canadian collaboration, though I do...

Details matter and I have not seen the paper, but if this pans out its potentially huge.

If all you care about is how the system works you are correct. If you want to intervene in a biological system you need detailed molecular mechanisms to design a new drug. However you can repurpose an existing drug, presuming there are suitable candidates, with little knowledge of detailed...

Lots of salicylate in lots of food. I presume you are using safe food lists. NAC = N-Acetyl Cysteine, a glutathione precursor. Theoretically it might help with salicylate problems, but I know of no concrete evidence, only theory. The enzymes attacked by salicylates are primarily regulated by...

Hi @SunnyK, our stories are similar. My Honours year and my PhD candidacy had me pushing myself too far, looking for a chance to upskill and get work I could do. Instead I pushed my more than mild ME until it was severe and I could no longer read, write nor even count to 3. I had already started...

Sleep is an active biochemical process, orchestrated in different ways at different times across the brain. Its initiated by, amongst other things, a release of prostaglandin D2. Sleep is not a passive letting go. If you are fixated on some thoughts or feelings that block sleep, then dealing...

I keep thinking about this. It might be urgently needed, we wont know until after it happens and we see the data. Given the incidence of infection and re-infection that we know of, planning future studiers and public health options may require this. As a guesstimate, not nearly reliable, I...

This kind of objective outcome needs to be more prevalent in a lot of research. We need to see it more often in ME research too.