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That seems like a pretty low bar to get over.. https://pedro.org.au/wp-content/uploads/PEDro_scale.pdf Looks like physios didn’t manage to fix their basic issues with the trial methodology, so they just made an easy version that everyone could pass.

Some characteristics that are often seen in pseudoscience, but do not by themselves always mean something is pseudoscientific: Ignoring or never seeking out contradictory data Vague and imprecise language Lack of boundaries for what the hypothesis applies to Asserting something that can’t be...

People often share things they think might be of interest to others without any personal preferences or opinions.

It isn’t that clearcut. The patients can decide that they perceive the impact to be negative, and that they therefore don’t want to go do it, but they don’t have a monopoly on deciding and a doctor shouldn’t give up attempting to persuade them if a reasonable neutral assessment is that impact...

Sure, there might be personal preferences here. I would personally need more than one bottle a day, so this would make me have to carry two or find other ways to get water in addition to the medication bottle. I’m used to pills from other issues before getting ME/CFS and it was never a bother.

But they have not proved that it’s directly related to PEM, they didn’t even show anything about symptom patterns. So they are either advocating for using an unproven and speculative endpoint, or for using it as a proxy for what’s essentially «overall health and functional capacity», just like...

Thanks for asking! They say that this water bottle regiment increases adherence to the medication regiment. I speculate that the increased adherence is because the participants perceive the higher doses to be beneficial, and not because the water bottle helps the medication work better or be...

The patient’s right to refuse any medical treatment without it negatively impacting the other medical care they receive, effectively protects their agency. That mechanism sometimes doesn’t work, but that’s a different question entirely. It is the doctor’s duty to make the best recommendations...

Did they test doing the same high daily doses but four times a day, or did they only test the high doses with water bottles? I suspect a lot of the motivation for adherence might have been based on the perceived benefit and not be related to the method. And some of them took quite a lot of other...

Why does these findings indicate abnormal aerobic metabolism? VO2 measures how much oxygen your body takes up. If I’ve understood things correctly, that can be affected by uptake (how much the lungs take up), transportation (heart and blood) and utilisation (muscles). Isn’t utilisation the only...

Systematic analyses of lipid mobilization by human lipid transfer proteins Abstract Line breaks added Lipid transfer proteins (LTPs) maintain the specialized lipid compositions of organellar membranes1,2. In humans, many LTPs are implicated in diseases3, but for the majority, the cargo and...

I would love for negative findings to get some more attention. I don’t know if this would be the right place for that, but I think the field might benefit from a broader discussion about where people have looked and found nothing unusual. A call to publish (or at least pre-print or Qeios)...

A between group difference of 0.6. The MCID for NRS (primary endpoint) is 1-2 for chronic muscoskeletal pain. https://pubmed.ncbi.nlm.nih.gov/15207508/ I can’t find any info about how successful the blinding was.

The study enrolment page doesn’t contain any info to the patients whatsoever. You have to book a call with someone. https://unhidenow.org/study-enrollment/

How feasible is blinding with this drug? I can’t find any data on it. The outcomes were subjective, and if the participants were able to tell if they got the drug or placebo, it might influence their reporting.

I’d answer «I have no idea because I don’t see any use in speculating in that when I’m so far away from it».

Fig. 1 PCC performance on LASSI-L compared to HC. Figure Legend: FRA1 Free Recall List A Trial 1, CRA 1 Cued Recall List A Trial 1, CRA2Cued Recall List A Trial 2, FRB1 Free Recall List B Trial 1, CRB1 Cued Recall List B Trial 1, CRB2 Cued Recall List B Trial 2, SdFRA Short Delay Free Recall...

Yet another rehab trial with either subjective outcomes with no blinding or irrelevant objective outcomes that for the most part only measure adherence by proxy. Why not look at potentially useful data like step count, hours worked, wages or other things that might tell us if the patients are...

The first part of the article is about how their data shows that people that have a lot of symptoms have a lot of symptoms, and that people with more symptoms now tend to have more symptoms in the future. The second part is mostly propaganda for mind-body interventions. They don’t give any...

Open-label and subjective outcomes. What more can you ask for? Shame on you Switzerland and EU: The COI is extensive: