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Uhh... wrong no wrong. Nothing proven in this paper regarding development of disease. All they’ve shown is higher EBV activity is associated with having ME/CFS. Given all the mountains of conflicting evidence showing no real connection to herpes viruses, it’s much more likely that the underlying...

But to give a contrasting perspective on the ketogenic diet and intermittent fasting - the fact that doesn’t improve symptoms as strongly as in the beginning shouldn’t be a reason for dismissing it or not trying to further understand the clues it might be giving on ME pathology. The long-term...

Very true. For me the first month or so the improvement in symptoms was so immense relative to where I was that it felt like a remission (hence the thread title). Especially too since nothing else has ever worked in any way. But soon after that I started seeing that those initial improvements...

Exhausted in the figurative non-ME way, like exhausted from having to consciously try to ingest so many fat calories per day.

From my understanding, a therapeutic ketogenic diet, not just low-carb like many healthy people do to get some ketosis but very low carb, is effectively a fasting or caloric restriction mimetic, at least during the first few days. In both treatments, your body changes and starts burning fats and...

My belief is that it somewhat circumvents or alleviates a part of the cellular metabolic dysfunction at the core of this disease, or that it’s anti-inflammatory and counteracts part of some chronic inflammation driving symptoms, or actually both (which is what I really think). Based on my user...

I also made a clarification edit to that post since I agree with you I do not want it to be take the wrong way.

I understand, I'm just giving my experience and my N=1 observational experiments. From getting ME in January 2013 until 2018, when I slowly declined enough that I had to stop working temporarily, my exertion levels were pretty much the same, my environment was the same, my diet was the same...

Following up to my OP, I've now been on this diet for more than 1 1/2 years. Like most others here who have been on it long-term I haven't had any side effects or worsening from it. TLDR: following a more healthy long-term version of the diet continues to significantly help with symptoms but...

With 1mg / 3 days have you and your doctor seen any of the obvious side effects? i.e. metabolic: hyperglycemia, hyperlipidemia, hypertriglyceridemia or immunosuppression: increased infections, etc? EDIT: Any other side effects from long-term use? Could you quantify as best you can how much...

Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling Abstract O-linked N-acetylglucosamine, better known as O-GlcNAc, is a sugar post-translational modification participating in a diverse range of cell functions. Disruptions in the cycling of...

This is very interesting, for me the only treatments that ever worked and helped with symptoms are fasting and ketogenic diet. Every other treatment ever mentioned here (or on PR) or my ME specialist recommended that I tried never did anything, not even any placebo effect. If you read in this...

Regulation of Immune Responses by mTOR Abstract mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in integrating environmental cues in the form of growth factors, amino acids, and energy. In the study of the immune system, mTOR is emerging as a critical...

I also just thought of a potential connection to these research results and why rituximab works in an ME subgroup. mTOR activity also regulates immune responses and microenvironment in addition to cell cycle and metabolism. Increased mTOR activity will activate B cells via IL-2 (as well as...

mTOR isn’t a backup energy system. It’s one of the most important proteins at the center of the mammalian cell stress sensing pathways. Remember too here it’s the cellular biology definition of stress, so not necessarily bad just signals that require the cell the react and alter behavior. mTOR...

It could be due to the reasons laid out in this paper. Ex vivo lymphocytes are generally metabolically quiescent and respire at such a low rate that they measure at the bottom end of Seahorse detection range regardless of ME or healthy control. They need to be immortalized or stimulated in...

What I also like about the results they found is the plausible connection between ATP synthase inefficiency -> upregulation of mTORC1 to make up for ATP synthesis by other mitochondrial means -> mTORC1 hyperactivity causing many unwanted side effects such as inflammation etc. So connecting...

Well put. Or it’s changing their programming maybe not permanently but for a long enough time.

Two very intriguing papers by this new lab entering ME/CFS research (Fisher). It shows that the small ME/CFS research community desperately needs new groups with greater expertise in particular areas such as mitochondria and energy metabolism, e.g. how did no previous group studying ME mito ever...

Thread already exists on this topic https://www.s4me.info/threads/havana-syndrome-u-s-and-canadian-diplomats-targeted-with-possible-weapon-causing-brain-injury-and-neurological-symptoms.8655/