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If you can’t detox ammonia via the liver the brain and muscle can be utilised(2:20) and exercise increases the problem 3 fold (10:40) Would ammonia effect platelets as well

I’m wondering if I may have something like partial NAGS deficiency (slc13a3) and found this on very rare urea cycle disorders http://www.nucdf.org/documents/NORD_Physician_Guide_to_Urea_Cycle_Disorders.pdf

Pyruvate in general has been mentioned before in M.E Fluge and mella Ron Davis pyruvate normalises blood and so does copaxone And dr bhupesh prusty mentions PDP1 It raised my interest as I likely have a deficiency at PDP2 and something happening with a-ketogluterate in urine glutamate and...

One of the hallmarks was that it was a cluster outbreak very few mecfs are part of a cluster outbreak these days Could it of been a coronavirus in evolution at the outbreaks I remember some link to Far East as well

Interesting study,I wonder if there are any updates

https://www.newsmax.com/t/newsmax/article/968688?section=us&keywords=ivermectin-drug-virus&year=2020&month=05&date=22&id=968688&oref=r.search.yahoo.com I wonder if ivermectin works in a similar way to suramin Then the counter argument...

https://pubmed.ncbi.nlm.nih.gov/32500504/ SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts

If you have genes related to dementia risk (APOE)ect,are you more likely to develop M.E And severe COVID as a few papers have suggested. https://www.sciencemediacentre.org/expert-reaction-to-study-on-covid-19-and-a-faulty-gene-linked-to-dementia/ I may have risk due to PITX2 but I think this...

https://www.jns-journal.com/article/S0022-510X(20)30282-3/fulltext COVID-19-associated delayed posthypoxic necrotizing leukoencephalopathy

https://www.jns-journal.com/article/S0022-510X(20)30282-3/fulltext COVID-19-associated delayed posthypoxic necrotizing leukoencephalopathy

COVID-19 –associated Diffuse Leukoencephalopathy and Microhemorrhages https://pubs.rsna.org/doi/10.1148/radiol.2020202040

https://pubs.rsna.org/doi/10.1148/radiol.2020202040 COVID-19 –associated Diffuse Leukoencephalopathy and Microhemorrhages

I saw rituximab described as the only approved anti EBV therapy I wonder if assessed on a case by case basis if it might be useful to me

PITX2 activates PDP2 so theoretically I’ll have low pyruvate dehydrogenase as I have a point mutation in PITX2 https://iovs.arvojournals.org/article.aspx?articleid=2385923 And SLC13A3 https://iovs.arvojournals.org/article.aspx?articleid=2364484

Is it getting rid of ammonia that’s helping

AMMONIA, GLUTAMATE, AND NEUROTOXICITY One of the topics included https://en.m.wikipedia.org/wiki/Glutamine_synthetase

https://nutritionreview.org/2013/04/krebs-cycle-intermediates/

Are these classed as inborn errors of metabolism or mitochondrial disorders Is high or low glutamate a feature n-carbamyglutamate (carglumic acid) as treatment

Is it only a small piece of a herpes virus that’s reactivating and EBV is relevant here