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  1. Marco

    Analysis of data from 500k individuals in UK Biobank shows an inherited component to ME/CFS (Ponting blog)

    Would this be the same nematode that tends to get itself into a Dauer state?
  2. Marco

    Neuroscience News: Is a Stress Shot on the Horizon?

    My bold. Very interesting indeed.
  3. Marco

    The Dopamine Imbalance Hypothesis of Fatigue in Multiple Sclerosis

    Good grief (belatedy). That sounds exactly like me and rather unlike what is reported for ME/CFS. I refer to them as 'stroke-like' episodes where amongst other things I have transient episodic ataxia.
  4. Marco

    Patients with chronic fatigue syndrome do not score higher on the autism‐spectrum quotient than healthy controls, 2018, Bileviciute‐Ljungar et al

    I would have guessed the same and I do have some slight concerns about the reliability of self-assessment in a population wary about being associated with a 'neuropsychiatric' condition
  5. Marco

    Drinking baking soda could be an inexpensive, safe way to combat autoimmune disease

    Not addressing the underlying cause of course but by reducing inflammation associated with autoimmune diseases such as rheumatoid arthritis or lupus. It's a little bit garbled but as far as I can tell baking soda appears to reduce inflammation by inducing the cholinergic anti-inflammatory...
  6. Marco

    Glutamate and fatigue

    Another interesting one : Sleep Deprivation Distinctly Alters Glutamate Transporter 1 Apposition and Excitatory Transmission to Orexin and MCH Neurons http://www.jneurosci.org/content/38/10/2505 Now I'm feeling a little sleep deprived myself so I can't quite work out whether GLT1 is solely...
  7. Marco

    Glutamate and fatigue

    I've posted this in the non-ME/CFS related section but that doesn't rule out the possibility of relevance. Firstly a mouse model that implicates the glutamate transporter GLT-1 in the mediation of exercise induced fatigue (interesting that extracellular glutamate is increased but lactate is...
  8. Marco

    Leonard Jason wants ME/CFS patients to do a PEM survey

    Done. That wasn't too bad.
  9. Marco

    The missing link: why disabled people can’t afford to #DeleteFacebook

    I sometimes wonder what McEvedy and Beard would make of today's Guardian?
  10. Marco

    PACE trial TSC and TMG minutes released

    Simon Wessley once referred to PACE as "a thing of beauty" and that "HMS PACE did make it successfully across the Atlantic" (the latter being an interesting phrase in itself) ...
  11. Marco

    Rethinking the treatment of CFS — a reanalysis and evaluation of findings from a recent major trial of GET and CBT (2018) Wilshire et al.

    Here's a cluster of petards - very useful for getting rid of moles and other nuisances and give off quite a thunderclap :
  12. Marco

    United Kingdom: ME Research Collaborative (MERC) [was CMRC] news

    More from Eileen Marshall and Margaret Williams : http://www.meactionuk.org.uk/Problems_and_Solutions.htm No way of telling if the quotes are accurate.
  13. Marco

    Review article: Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?, 2018, Newberry et al

    The problem is that the effect on the GI tract in both cases is likely to affect the microbiome and while IBS is common in ME/CFS there doesn't appear to be any distinguishing underlying pathology of the GI tract. If they could point to X disease where a reduction in microbiome diversity...
  14. Marco

    Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Cook, Light +

    While it's welcome to see research that appears to chime with personal experience (when subject to a stressor my brain turns to mush) unfortunately the results are open to interpretation that might support the BPS model. No criticism of the researchers - it's just the way it is. I could...
  15. Marco

    Article in French Newspaper «J'écris ma souffrance pour affirmer que je suis vivant malgré tout»

    That's pretty much my experience as well and in comparison to the NHS there really is no comparison (obviously the NHS compares unfavourably and this was based on my experience 12 plus years ago - I'm sure it hasn't improved). One thing I have noticed is that French doctor's aren't big on...
  16. Marco

    Long term depression associated with 'neuroinflammation'

    @Hip This paper is pretty much as I remember it : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784364/ As I read that - if symptoms don't resolve within the expected week to 10 days then PCS is suspected if not diagnosed de facto. Anyway, it's an interesting 'syndrome' and one of the few...
  17. Marco

    Long term depression associated with 'neuroinflammation'

    I'm not sure this is the case. PCS not resolving after any physical brain damage is assumed to have healed brings out the usual 'psychological factors' explanations but PCS can persist for many more months or years and to assume a non-physiological reason is just lazy.
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