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As an aside I watched the bbc documentary about the novichok poisonings recently and this list of symptoms seemed very familiar! I suppose it's not surprising that the nerve agent sarin would give the same symptoms if they're both inhibiting acetylcholine breakdown

The EBV negative MS cases could also either be incorrect MS diagnoses or false negative serology. I don't know what the error rates are for these tests but with the large cohort here it would presumably not be surprising to see a couple no? What is the definition of causation in your opinion...

Thanks Andy! This is really helpful. That really is an absolutely shocking paragraph to read.

Signed. What's the nature of this petition? Is it like the German one where reaching the quorum results in some government hearing? Or is it more like a change.org petition?

I am extremely worried about the quality of this survey

Question about the PACE trial: It's quoted in Bruce Levin's youtube video (timestamped: ) and in David Tuller's blog that (https://www.virology.ws/2020/01/13/trial-by-error-the-2018-pace-reanalysis-and-the-smcs-expert-appraisals/) that "13% of participants were already “within normal range” or...

That's really interesting. So you might expect protein coding mutations to be fairly binary most of the time - either total loss of function or synonymous/little change. Whereas non coding region mutations have a continuous effect ie eQTLs. I imagine this can get very complicated very quickly...

I recall a twitter thread relatively recently discussing a new paper from whole exome sequencing, looking for the contribution of rare variants in collapsed gene models. I recall that the conclusions were that there were no significants hits for ME, which when combined with the lack of evidence...

Something about the hashtag #TeamClots makes me laugh. I think it's that it sounds like they're on the side of the clots rather than against them

This 2010 review ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998922/ ) suggests RBCs use ATP to regulate deformability, becoming more rigid in low ATP conditions when tested in vitro. Given there's been various pieces of evidence suggesting metabolic problems in ME/CFS, it could also be that...

I do like the idea of a positive feedback loop causing PEM. They are suggesting the RBCs are deformable in normal O2 conditions though, so perhaps this could read instead like: Exertion -> lower local [O2] -> decreased RBC deformability -> lower local [O2] etc Will be cool to see if this is...

Is there a source for where he reports on the size of the "something in the blood"? I think this is very interesting. When you say bigger than a molecule do you know if he means a small molecule (a metabolite eg glucose/amino acids etc) or a protein (which are gigantic biomolecules). You're...

From the Axcella website: "AXA1125 is an EMM composition of six amino acids and derivatives." If it is simply amino acids then is this essentially a nutritional supplement? 67.8 grams sounds like a lot!

Is anything known about its mechanism of action? Is this a small molecule with a known target?

Is it likely that the Royal Colleges continuing to take this position will cause problems with obtaining funding for the kind of research we need? Does their influence stretch to the NIHR and MRC as far as we know? Presumably their opinion won't matter all too much when it comes to the...

It would definitely be a good thing for BACME and it's fontline clinicians to be more connected to the biomedical research community. How many of their OTs/therapists are even aware of DecodeME for instance? I personally know of some who weren't before I told them recently, which is strange when...