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Looks like a good study for us to get involved in. Could generate some valuable data.

Yes, it was quite enlightening, wasn't it? I remember when Masson's "Assualt on Truth" came out in the 80s, which revealed all the Anna O shenanigans. The psychodynamic crew did everything they could to first prevent Masson accessing the letters/source materials, and then later to destroy his...

If I had real depression - the full blown emptiness and despair - I would certainly try chatting to someone with a listening ear first before swallowing the pills. But I'd probably stay away from those who practice CBT to the letter. It takes a quite a strong view on some things - like the idea...

This article by Stone et al: http://jnnp.bmj.com/content/73/3/241: And this one (also by Stone et al) is a cracker: https://link.springer.com/article/10.1007/s00415-011-6111-0 The whole article goes on to explore which neurological diseases are most commonly associated with “functional overlay”.

My point was that what we think we know for sure about CBT's effectiveness, we actually don't know for sure. Some aspects might be effective for some things in some situations. But the evidence that's out there is mostly so biased that it amounts to no evidence at all. We just don't know.

This is an interesting line, which sounds oddly familiar: Remind anyone of the concept of "functional overlay"?

Looking at @Chesire's original article, I noticed this: I wonder if we really know that for sure - that CBT works. Given the poor designs used to assess its efficacy, I would say we just don't know yet. This made me think on it all, progress and science and everything. We humans can easily...

Wasn't cocaine an ingredient in the original coca-cola - hence the name? Or am I misremembering?

Amen to that, @Cheshire. And as @TiredSam will attest, Freud's still alive and strong in some corners of the world...

That was actually incredibly clear - and useful @Jonathan Edwards. I was confused about those diseases that are sort of in the middle of the spectrum, like Crohn's. I recently got diagnosed with one of those hereditary autoinflammatory diseases you mentioned above (won't say which one). But a...

I'm a bit conflicted about the personality disorder question. Mental health professionals treat ppl with this diagnosis with utter contempt. So I agree the diagnosis should be banned, it does more harm than good. Also, I'm not convinced it's a disorder as such. Just a problematic way of...

:jawdrop::jawdrop::jawdrop:!! What do they talk about then? What a nice day it is?

Hi @Josie. Sorry, I only just saw your message. I was struck by this. A few of us here on the forum have described a similar thing, a sort of paradoxical stress response. You get a little symptomatic relief during the stress, and when that passes, then the symptoms come back to bite you in the...

These results are pretty consistent, imo. When they isolated those studies that used high sensitivity CRP assays, every single one showed a trend towards higher CRP in the ME patients vs. controls. The difference is pretty tiny, which suggests that it might be driven by a subset of patients...

Interesting, but I just feel like they are trying to overextend the dopamine idea to explain fatigue. Since all the products of that overexcited immune system are running about the body as well as the brain, and since they interfere with energy production and impede functioning in all sorts of...

Yes, I think so too!

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines & emotional behavior Miyajima, M., et al. Nature Immunology 18, 1342–1352 (2017) doi:10.1038/ni.386 https://www.nature.com/articles/ni.3867 From the abstract: Okay, its mouse science...

I'm not sure this is technically allowed, but here is the fulltext (please note that posting this link might be a violation of the forum rules - I've reported myself - so be aware this post might need to be removed quite soon).

@MeSci, thanks for posting. If you're still reading here, would you mind adding the link to the abstract to your opening post? Its helpful to have all that info in an easily accessible place. This one: http://journals.sagepub.com/doi/abs/10.1177/1742395317746470

How awful, @Arnie Pye! Its amazing just how long we put up with this sort of shit, isn't it? Because we're told they know their stuff, and we're taught to be agreeable and cooperative patients. I saw a psychiatrist when I first got ill in my 20s, mainly because I wanted support and at that...