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    First test for long Covid gets EU approval, August 2022 - IncellDx incellKINE Long COVID test

    But wait, how can she have the elevated cytokines immune signature if the Lightning Process already cured her?... Phil Parker must really be scratching his head over that one.
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    Endothelial dysfunction in ME/CFS patients, 2023, Sandvik, Mella, Fluge et al

    Thanks very much for your summary. I found this diagram in an image search (ref). I think this is what Sandvik et al did, isn't it? Helps to see the visual representation.
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    UK: Dr Sarah Myhill

    Dr Myhill’s response. She says she applied to deregister in August 2020 but the GMC launched further investigations and refused her request. https://www.drmyhill.co.uk/wiki/Response_to_GMC_Action_to_suspend_me_from_its_Register_-_1_February_2023
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    UK: Dr Sarah Myhill

    I’m not sure what effect this will have as I thought she’d given up her medical licence already due to insurance issues, and was just practicing as a naturopath? Shame, as a more holistic approach such as she aspires to potentially has some value if practiced responsibly and where appropriate...
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    Experience with LDN? low dose naltrexone

    I've tried LDN and found it had a useful effect and seemed to work on a deeper level than other treatments I've tried, but it was only a temporary improvement in my case. Once I'd carefully worked up to a therapeutic dose, which started around the 2.5 mg range and above for me I noticed reduced...
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    Study finds first direct evidence of a link between low serotonin and depression

    Study finds first direct evidence of a link between low serotonin and depression From the Guardian, science correspondent: Link to the study: BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE.
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    Closed UK: DecodeME updates, was recruitment thread.

    Thanks everyone involved in setting up the DecodeME study. These are just some thoughts I’ve had; sharing in case helpful at all. As another post mentioned, I couldn’t remember if I’d signed up already or not. I remembered signing up for something a while ago but couldn’t remember exactly what...
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    Closed UK: DecodeME updates, was recruitment thread.

    It may have been said somewhere and I missed it, but do patients need to fulfil both sets of the criteria being used, or just one or the other, to qualify for DNA sampling?
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    Closed UK: DecodeME updates, was recruitment thread.

    Absolutely, agree it's important that people complete the questionnaire honestly and without bias to provide the best possible data quality for the survey. I did and I've received an email thanking me and letting me know they won't be requesting a saliva sample. I'm familiar with both sets of...
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    Review Repeated maximal exercise tests of peak oxygen consumption in people with ME/CFS: a systematic review and meta-analysis, Franklin & Graham, 2022

    ^^at anaerobic threshold^^ From the abstract "The pooled mean decrease in peak work rate (five studies), measured at retest, was greater in ME/CFS by −8.55 (95% CI −15.38 to –1.72) W. The pooled mean decrease in work rate at anaerobic threshold (four studies) measured at retest was greater in...
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    Edzard Ernst: Quackery is on the rise, and the placebo effect is part of the problem

    May 9, 2019 Placebo: Can the Mind Cure You? https://gimletmedia.com/shows/science-vs/5whgzd There was some interesting stuff here in this podcast about how a conditioned response to a uniquely flavoured drink could produce measurable changes in immune function… weird!
  12. H

    Astellas' Bocidelpar - drug to restore mitochondrial function

    Sounds novel/ interesting, but does anyone have an inkling how promising this line of research is and how relevant to ME/CFS?
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    Protocol Trial registration: Low-dose Naltrexone for Post-COVID Fatigue Syndrome, 2022, Luis Nacul, British Columbia Women's Hospital & Health Centre

    Personally, when I tried LDN, I found the syrupy liquid mixture, that’s measured out with an oral syringe, more effective than the capsules. It was supplied by Dickson Chemist, Glasgow. I don’t know why, but that was my experience. With the capsules, from a different pharmacy, that I tried...
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    Brain Fog Article in Law Society Gazette

    How to fix forgetfulness and woolly thinking “Forgetting words, woolly thinking and a poor attention span are becoming increasingly common, but what’s behind it?” There’s a similar article in the DT, appropriating and generalising our term of ‘brain fog’, it’s becoming part of everyday...
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    Combination of whole body cryotherapy with static stretching ... reduces fatigue and improves functioning of the [ANS] in CFS, 2022, Kujawski et al

    I’m wondering what happens if you get stuck inside the cryo machine?! That would be my fear.
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    Nasobiotex L. Sakei Probiotic Powder for sinus microbiome - anyone tried it?

    Has anyone found a source for Lactobacillus sakei in the UK? Thanks. I'd like to try this for my sinus issues, but shipping from US supplier is $50.
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    Closed 2022 Pilot study in Norway - Daratumumab in ME/CFS

    Interesting... so they still think there might be something more to explore here, with using monoclonal antibodies for immunosuppression. This time targeting a slightly different array of immune cells than they did with rituximab (which binds to CD20). "Daratumumab, sold under the brand name...
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    Nature - Long COVID after breakthrough SARS-CoV-2 infection by Al-Aly et al, 2022

    Washington Post article, 25th May 2022 Vaccines may not prevent many symptoms of long covid, study suggests
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