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    TisBest $50 Charity Gift Card (free) to the first 20,000 who sign up

    https://www.tisbest.org/redefinegifting/ Browse charities here I've found these amongst others, I think it's all American charities so I'm not very familiar with which are the good ones to support. Solve ME/CFS Initiative (Solve M.E.) IACFS/ME
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    Immune stimulation by vaccination e.g. Staphylococcus Toxoid Vaccine, BCG

    Finally, an upside to Brexit? ;) We could start up the old company again with the original manufacturing process. I think part of the issue was that the vaccine contained mercury-based preservatives and so I’m quite glad these were deemed in need of improvement, but apparently that would also...
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    Heart rate variability is not associated with multiple chemical sensitivity in a cross-sectional population-based study [...], 2024, Bjerregaard et al

    Who says multiple chemical sensitivity is a functional somatic disorder? I think that statement is wrong, and as it turns out unsupported by their study.
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    What medical specialty should look after ME/CFS?

    Absolutely not rehab, that would be the worst. To a man with a hammer, everything is a nail. What we need for the moment is specialist/ consultant general physicians with the time to listen and think, and experience of managing chronic illnesses. Until the precise mechanism is elucidated, then...
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    London resilience clinic : Holistic Chronic Fatigue Treatment

    I'd be curious to try it. The only possible problem is that I get palpitations sometimes and might have an occasionally irregular heart beat, and I think this might be a contraindication.
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    London resilience clinic : Holistic Chronic Fatigue Treatment

    In the video she references medical cannabis, which is legal in the UK through certain licensed practitioners I think.
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    Maeve Boothby O'Neill - articles about her life, death and inquest

    Surprisingly good articles from The Guardian, perhaps they’re trying to redeem themselves after that awful one by Dr Miller.
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    Exhaustion in ME/CFS, what is it and what causes it - discussion thread

    I've not read the whole thread, but to me it's like the fatigue and exhaustion one gets with flu. I think it has to be immune mediated, if we're talking about post-exertion malaise then I think it has to be, otherwise, what other mechanism could cause the delayed onset and protracted recovery to...
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    Opinion: ‘You don’t want to get better’: the outdated treatment of ME/CFS patients is a national scandal - George Monbiot

    A great article and thanks to George Monbiot. This is the reality of what's happened to us and how people with ME/CFS have been horribly let down. This bit above though was a bit muddled, I thought. Those first two links are both referencing the Walitt et al paper in Nature Communications, but...
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    Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2-1 related Pangolin Coronavirus: 2024, Lai et al

    https://nypost.com/2024/01/16/news/covid-19-strain-kills-100-of-infected-mice-in-chinese-lab-study/ The experts quoted at the end of this tabloid piece are quite horrified. It appears to be a real paper and I fear we as a species haven’t learnt the lessons of the Covid-19 pandemic. Far from it...
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    Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients

    I think it’s suggesting that the serum and CSF contained neutralising antibodies, but haven’t read the paper either.
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    BMJ Neurology Topic Collection: "Advances in Functional Neurological Disorder", 2023

    :laugh: “Functional somatic syndromes: one or many?” S Wessely et al. Lancet. 1999.
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    Anomalies in the review process and interpretation of the evidence in the NICE guideline for (CFS & ME), 2023, White et al

    I think the “off” is a remnant from his first draft, where he was telling the authors what they could do.
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    Times (Peta Bee) Exhausted? You may have hyper-fatigue

    It's a bit perturbing to have fatigue ('hyper-fatigue'? More catchy?...) identified as a consumer trend but some of the general advice on TATT seems reasonable enough just so long as they don't start amalgamating it with ME/CFS.
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    CNN: Zero-calorie sweetener (erythritol) linked to heart attack and stroke, study finds

    I think the stevia is okay so far as we know, just the erythritol that’s almost just used as a bulking agent in this case has been flagged up for concern. I just use micro doses of stevia to sweeten cocoa for a hot chocolate drink and add some coconut plant milk, tastes delicious!
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    CNN: Zero-calorie sweetener (erythritol) linked to heart attack and stroke, study finds

    I wonder about xylitol? That’s a sugar alcohol too. It’s good for your teeth as it inhibits bacterial adhesion, but is it molecularly similar to erythritol and would the same concerns apply?
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    Endothelial dysfunction in ME/CFS patients, 2023, Sandvik, Mella, Fluge et al

    Thanks. It's not clear what product the EFSA ruling is concerning. The application is from Praline i Čokolada j.d.o.o., who, so far as I can tell are (or were) a company manufacturing sweets and chocolate bars in Croatia. It translates as praline and chocolate. So one imagines it might relate to...
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    Endothelial dysfunction in ME/CFS patients, 2023, Sandvik, Mella, Fluge et al

    Would grape seed extract (GSE) be worth trying? This quote below is from marketing literature so apologies for that, but gives you the idea - in animal models GSE activated the enzyme (eNOS) that produces nitric oxide. The information is focused on blood pressure regulation but seems there is...
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    Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue..., 2023, Guo,Lipkin et al

    FEBRUARY 8, 2023 expert reaction to two studies on the gut microbiome and ME/CFS https://www.sciencemediacentre.org/expert-reaction-to-two-studies-on-the-gut-microbiome-and-me-cfs/
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